NiSO4-catalyzed C-H activation/C-S cross-coupling of 1,2,3-triazole N-oxides with thiols

被引：16

作者：

Zhu, Jiayi ^{[1
]}

Chen, Yu ^{[1
]}

Lin, Feng ^{[1
]}

Wang, Baoshuang ^{[1
]}

Chen, Zhengwang ^{[1
]}

Liu, Liangxian ^{[1
]}

机构：

[1] Gannan Normal Univ, Key Lab Organopharmaceut Chem Jiangxi Prov, Ganzhou 341000, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 12期

关键词：

IN-VIVO EVALUATION; BOND FORMATION; ARYL; FUNCTIONALIZATIONS; THIOLATION; AMINATION; SULFIDES; AZOLES;

D O I：

10.1039/c4ob02586e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient nickel-catalyzed protocol for C-S cross-coupling through the direct functionalization of 2-aryl-1,2,3-triazole N-oxide C-H bonds with aryl or alkyl thiols, or diphenyl disulfide has been developed. The targeted N+-O- bond cleavage can be observed during the reaction, and thus obviates the need to use an additional deoxygenation step. This new protocol for the preparation of thiolated 2-aryl-1,2,3-triazoles appears to offer good yields with high regioselectivity, mild conditions, and a wide substrate scope.

引用

页码：3711 / 3720

页数：10

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