Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives

被引：15

作者：

Cavalcante, Joeliton dos Santos ^{[1
]}

Nogueira Junior, Francisco Assis ^{[2
,3
]}

Bezerra Jorge, Roberta Jeane ^{[2
,3
]}

Almeida, Cayo ^{[4
]}

机构：

[1] Sao Paulo State Univ, Botucatu Med Sch FMB, Grad Program Trop Dis, Botucatu, SP, Brazil

[2] Univ Fed Ceara, Dept Physiol & Pharmacol, Fortaleza, Ceara, Brazil

[3] Univ Fed Ceara, Drug Res & Dev Ctr, Fortaleza, Ceara, Brazil

[4] Fed Univ ABC, Ctr Math Comp Sci & Cognit, Sao Paulo, Brazil

来源：

TOXICON | 2021年 / 201卷

关键词：

Snakebite; Bothrops; Inflammation; Nociception; Tissue damage; PHOSPHOLIPASES A(2); JARARACA VENOM; NEUROPATHIC PAIN; NITRIC-OXIDE; SUBSTANCE-P; PROINFLAMMATORY CYTOKINES; ARACHIDONIC-ACID; MOOJENI VENOM; TNF-ALPHA; PAW EDEMA;

D O I：

10.1016/j.toxicon.2021.08.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Snake venoms are substances mostly composed by proteins and peptides with high biological activity. Local and systemic effects culminate in clinical manifestations induced by these substances. Pain is the most uncomfortable condition, but it has not been well investigated. This review discusses Bothrops snakebite-induced nociception, highlighting molecules involved in the mediation of this process and perspectives in treatment of pain induced by Bothrops snake venoms (B. alternatus, B. asper, B. atrox, B. insularis, B. jararaca, B. pirajai, B. jararacussu, B. lanceolatus, B. leucurus, B. mattogrossensis, B. moojeni). We highlight, the understanding of the nociceptive signaling, especially in snakebite, enables more efficient treatment approaches. Finally, future perspectives for pain treatment concerning snakebite patients are discussed.

引用

页码：105 / 114

页数：10

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