Preparation, characterization, and in vitro diffusion study of nonwoven electrospun nanofiber of curcumin-loaded cellulose acetate phthalate polymer

被引：48

作者：

Ravikumar, Rramaswamy ^{[1
,4
]}

Ganesh, Mani ^{[1
]}

Ubaidulla, Udumansha ^{[2
]}

Choi, Eun Young ^{[3
]}

Jang, Hyun Tae ^{[1
]}

机构：

[1] Hanseo Univ, Dept Chem Engn, 360 Daegok Ri, Seosan 356706, Chungcheongnam, South Korea

[2] CL Baid Metha Coll Pharm, Madras 97, Tamil Nadu, India

[3] Hanseo Univ, Dept Cosmetol, 360 Daegok Ri, Seosan 356706, Chungcheongnam, South Korea

[4] Hanseo Univ, Dept Adv Mat & Engn, 360 Daegok Ri, Seosan 356706, Chungcheongnam, South Korea

来源：

SAUDI PHARMACEUTICAL JOURNAL | 2017年 / 25卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Curcumin; Cellulose acetate phthalate; Nanofiber; In vitro; Transdermal; ANTIOXIDANT; DELIVERY; NANOPARTICLES; TECHNOLOGIES; RELEASE; GEL;

D O I：

10.1016/j.jsps.2017.02.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Novel curcumin (CUR)-loaded cellulose acetate phthalate (CAP) nonwoven electrospun nanofiber (NF) transdermal mat was developed and evaluated for its in vitro CUR diffusion properties. Various CAP solutions from 5 to 20 wt% were tested; 17.5 wt% was found to be a suitable concentration for NF fabrication without defects, such as bubble or ribbon structures. The selected wt% CAP solution was loaded with CUR and electrospun into NFs. The prepared CUR-loaded NFs were characterized using scanning electron microscopy, X-ray diffraction, ultraviolet-visible spectroscopy, thermogravimetric analysis (TGA), and in vitro diffusion studies. The as-prepared fibers demonstrated controlled in vitro transdermal delivery of CUR for up to 24 h. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：921 / 926

页数：6

共 44 条

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