Mammary stem cell number as a determinate of breast cancer risk

被引：54

作者：

Ginestier, Christophe ^{[1
]}

Wicha, Max S. ^{[1
]}

机构：

[1] Univ Michigan, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

BREAST CANCER RESEARCH | 2007年 / 9卷 / 04期

关键词：

D O I：

10.1186/bcr1741

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ' cancer stem cell hypothesis' posits that cancers, including breast cancer, arise in tissue stem or progenitor cells. If this is the case, then it follows that the risk for developing breast cancer may be determined in part by the number of breast stem/progenitor cells that can serve as targets for transformation. Stem cell number may be set during critical windows of development, including in utero, adolescence, and pregnancy. The growth hormone/insulinlike growth factor-1 axis may play an important role in regulating breast stem cell number during these developmental windows, suggesting an important link between this signaling pathway and breast cancer risk.

引用

页数：2