Mammary stem cell number as a determinate of breast cancer risk

被引：54

作者：

Ginestier, Christophe ^{[1
]}

Wicha, Max S. ^{[1
]}

机构：

[1] Univ Michigan, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

BREAST CANCER RESEARCH | 2007年 / 9卷 / 04期

关键词：

D O I：

10.1186/bcr1741

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ' cancer stem cell hypothesis' posits that cancers, including breast cancer, arise in tissue stem or progenitor cells. If this is the case, then it follows that the risk for developing breast cancer may be determined in part by the number of breast stem/progenitor cells that can serve as targets for transformation. Stem cell number may be set during critical windows of development, including in utero, adolescence, and pregnancy. The growth hormone/insulinlike growth factor-1 axis may play an important role in regulating breast stem cell number during these developmental windows, suggesting an important link between this signaling pathway and breast cancer risk.

引用

页数：2

共 11 条

[1] Growth patterns and the risk of breast cancer in women [J].

Ahlgren, M ;

Melbye, M ;

Wohlfahrt, J ;

Sorensen, TIA .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (16) :1619-1626

[2] Growth hormone increases Stat5 and Stat1 expression in lactating goat mammary gland: a specific effect compared to milking frequency [J].

Boutinaud, M ;

Jammes, HN .

DOMESTIC ANIMAL ENDOCRINOLOGY, 2004, 27 (04) :363-378

[3] Role of growth hormone receptor signaling in osteogenesis from murine bone marrow progenitor cells [J].

Cool, SM ;

Grünert, M ;

Jackson, R ;

Li, H ;

Nurcombe, V ;

Waters, MJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 338 (02) :1048-1058

[4] In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells [J].

Dontu, G ;

Abdallah, WM ;

Foley, JM ;

Jackson, KW ;

Clarke, MF ;

Kawamura, MJ ;

Wicha, MS .

GENES & DEVELOPMENT, 2003, 17 (10) :1253-1270

[5] Acromegaly and cancer [J].

Jenkins, PJ .

HORMONE RESEARCH, 2004, 62 :108-115

[6] The GH-IGF-I axis and breast cancer [J].

Laban, C ;

Bustin, SA ;

Jenkins, PJ .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2003, 14 (01) :28-34

[7] Role of birthweight in the etiology of breast cancer [J].

Michels, Karin B. ;

Xue, Fei .

INTERNATIONAL JOURNAL OF CANCER, 2006, 119 (09) :2007-2025

[8] Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis [J].

Savarese, Todd M. ;

Strohsnitter, William C. ;

Low, Hoi Pang ;

Liu, Qin ;

Baik, Inkyung ;

Okulicz, William ;

Chelmow, David P. ;

Lagiou, Pagona ;

Quesenberry, Peter J. ;

Noller, Kenneth L. ;

Hsieh, Chung-Cheng .

BREAST CANCER RESEARCH, 2007, 9 (03)

[9] HYPOTHESIS - DOES BREAST-CANCER ORIGINATE INUTERO [J].

TRICHOPOULOS, D .

LANCET, 1990, 335 (8695) :939-940

[10] Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor system [J].

van Garderen, E ;

Schalken, JA .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2002, 197 (1-2) :153-165

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