From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

被引：187

作者：

Han, Hui ^{[1
,2
]}

Yi, Bao ^{[1
]}

Zhong, Ruqing ^{[1
]}

Wang, Mengyu ^{[1
]}

Zhang, Shunfen ^{[1
]}

Ma, Jie ^{[3
]}

Yin, Yulong ^{[3
,4
]}

Yin, Jie ^{[3
]}

Chen, Liang ^{[1
]}

Zhang, Hongfu ^{[1
,3
]}

机构：

[1] Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

[2] Univ Liege, Precis Livestock & Nutr Unit, Gembloux Agrobio Tech, Passage Deportes 2, B-5030 Gembloux, Belgium

[3] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China

[4] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agro Ecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China

来源：

MICROBIOME | 2021年 / 9卷 / 01期

关键词：

Gut microbiota; Appetite; Metabolites; Hormone; Immune; GAMMA-AMINOBUTYRIC-ACID; CHAIN AMINO-ACIDS; FOOD-INTAKE; PEPTIDE YY; FEED-INTAKE; INTESTINAL MICROBIOTA; INSULIN SENSITIVITY; SERUM METABOLOME; BARRIER FUNCTION; ENERGY-BALANCE;

D O I：

10.1186/s40168-021-01093-y

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut microbiota, which develop the intricate interactions to manipulate the metabolic requirements and hedonic feelings. Gut microbial metabolites and components act as appetite-related signaling molecules to regulate appetite-related hormone secretion and the immune system, or act directly on hypothalamic neurons. Herein, we summarize the effects of gut microbiota on host appetite and consider the potential molecular mechanisms. Furthermore, we propose that the manipulation of gut microbiota represents a clinical therapeutic potential for lessening the development and consequence of appetite-related disorders.

引用

页数：16

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