Human embryonic stem cell-derived melanocytes exhibit limited immunogenicity

被引：4
作者：
Wang, Jinqi [1 ]
Zeng, Xuanhao [1 ]
Liu, Yating [1 ]
Lian, Weiling [1 ]
Lv, Haozhen [1 ]
Wei, Kelu [1 ]
Zhang, Qi [1 ]
Xu, Jinhua [1 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200040, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2021年 / 573卷
基金：
中国国家自然科学基金;
关键词：
Embryonic stem cells; Melanocyte; Vitiligo; Regenerative medicine; Immunogenicity; GENERATION; EXPRESSION;
D O I：
10.1016/j.bbrc.2021.07.103
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although surgical interventions have become optional for refractory vitiligo, grafting related injuries is inevitable. Embryonic stem cell (ESC) derivatives can be used in transplantation to address this issue, but the immune rejection due to allogeneic transplantation is of great concern. To investigate the immunogenicity of ESC derived melanocytes (ES-MC), we established a co-culture system of ES-MC and allogeneic PBMC. The results showed that ES-MC were similar to human primary melanocytes, with low expression of immune related molecules, and limited capability of stimulating allogeneic lymphocytes in vitro. Taken together, our findings confirm that ES-MC are of limited immunogenicity, providing new insights into the application of ES-MC in the regenerative medicine such as treating vitiligo. (c) 2021 Elsevier Inc. All rights reserved.
引用
收藏
页码：151 / 157
页数：7
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