lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer

被引：3

作者：

Song, Linlin ^{[1
]}

Wang, Linlin ^{[2
]}

Pan, Xiaoli ^{[3
]}

Yang, Caihong ^{[1
]}

机构：

[1] Ningxia Med Univ, Gen Hosp, Dept Gynecol, Yinchuan, Peoples R China

[2] Ningxia Med Univ, Gen Hosp, Med Lab Ctr, Yinchuan, Peoples R China

[3] Ningxia Med Univ, Gen Hosp, Dept Pathol, Yinchuan, Peoples R China

来源：

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH | 2020年 / 53卷 / 01期

关键词：

lncRNA; OIP5-AS1; Cervical cancer; miR-143-3p; ROCK1; LONG NONCODING RNA; OSTEOSARCOMA; EXPRESSION;

D O I：

10.1590/1414-431X20198883

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) is one kind of cytoplasmic long non-coding RNA (lncRNA), which has been demonstrated to play a critical function in multiple cancers. However, the detailed mechanism of OIP5-AS1 in the regulation of cervical cancer progression is still obscure. Here, we demonstrated that lncRNA OIP5-AS1 was upregulated in cervical cancer and was correlated with poor prognosis by bioinformatics studies. OIP5-AS1 depletion inhibited cell proliferation and promoted cell apoptosis in cervical cancer cells. Furthermore, we clarified that ROCK1 was the downstream effector of OIP5-AS1 and OIP5-AS1 acted as a molecular sponge of miR-143-3p. Finally, we verified that OIP5-AS1 exerted its function in the regulation of cervical cancer progression via interacting with miR-143-3p to regulate ROCK1 expression. Our study revealed novel mechanisms about how lncRNA OIP5-AS1 executed its function in cervical cancer and thus provided potential therapeutic targets for the disease.

引用

页数：10

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