Mosquito heat seeking isdriven by an ancestral cooling receptor

被引：77

作者：

Greppi, Chloe ^{[1
,2
]}

Laursen, Willem J. ^{[1
,2
]}

Budelli, Gonzalo ^{[1
,2
]}

Chang, Elaine C. ^{[1
,2
]}

Daniels, Abigail M. ^{[1
,2
]}

Van Giesen, Lena ^{[1
,2
]}

Smidler, Andrea L. ^{[3
,4
]}

Catteruccia, Flaminia ^{[3
]}

Garrity, Paul A. ^{[1
,2
]}

机构：

[1] Brandeis Univ, Dept Biol, Waltham, MA 02453 USA

[2] Brandeis Univ, Volen Ctr Complex Syst, Waltham, MA 02453 USA

[3] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[4] Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

来源：

SCIENCE | 2020年 / 367卷 / 6478期

基金：

美国国家科学基金会; 瑞士国家科学基金会;

关键词：

TEMPERATURE; ATTRACTION; SENSILLA;

D O I：

10.1126/science.aay9847

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mosquitoes transmit pathogens that kill >700,000 people annually. These insects use body heat to locate and feed on warm-blooded hosts, but the molecular basis of such behavior is unknown. Here, we identify ionotropic receptor IR21a, a receptor conserved throughout insects, as a key mediator of heat seeking in the malaria vector Anopheles gambiae. Although lr21a mediates heat avoidance in Drosophila, we find it drives heat seeking and heat-stimulated blood feeding in Anopheles. At a cellular level, Ir21a is essential for the detection of cooling, suggesting that during evolution mosquito heat seeking relied on cooling-mediated repulsion. Our data indicate that the evolution of blood feeding in Anopheles involves repurposing an ancestral thermoreceptor from non-blood-feeding Diptera.

引用

页码：681 / +

页数：28

共 32 条

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