Chemoenzymatic synthesis of boron-containing chiral amines and amides

被引：16

作者：

Andrade, Leandro H. ^{[1
]}

Barcellos, Thiago ^{[1
]}

Santiago, Carolina G. ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Chem, BR-05508900 Sao Paulo, Brazil

来源：

TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 19期

基金：

巴西圣保罗研究基金会;

关键词：

NEUTRON-CAPTURE THERAPY; CROSS-COUPLING REACTION; KINETIC RESOLUTION; ORGANIC-SYNTHESIS; ACID INHIBITORS; LIPASE; ACYLATION; PROTEASOME; CHEMISTRY; CANCER;

D O I：

10.1016/j.tetasy.2010.09.011

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The first application of lipases as catalysts to obtain optically active boron-containing amines and amides is described. We studied several reaction conditions to achieve the kinetic resolution of boron-containing amines via enantioselective acylation mediated by Candida antarctica lipase B (CAL-B). Excellent enantioselectivity (E>200) and high enantiomeric excess (up to >99%) of both the remaining amines and amides were obtained. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2419 / 2424

页数：6

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