Synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

被引：16

作者：

Cheung, M ^{[1
]}

Harris, PA ^{[1
]}

Lackey, KE ^{[1
]}

机构：

[1] Glaxo Wellcome Inc, Res Triangle Pk, NC 27709 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)02219-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,3-Dihydro-2N-indol-3-ones (oxindoles) and 1,3-dihydro-2H-pyrrolopyridin-2-ones (azaoxindoles) are useful scaffolds that have been explored for various pharmaceutical uses. Herein we report the synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one (5) and its derivatives, and the application of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones (diazaoxindoles) as novel scaffold to kinase research areas. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：999 / 1001

页数：3

共 20 条

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