Serum osteocalcin is related to abdominal obesity in Korean obese and overweight men

被引：31
作者：
Kim, Sang-Hwan [2 ]
Lee, Ji-Won [1 ]
Im, Jee-Aee [3 ]
Hwang, Hee-Jin [2 ]
机构：
[1] Yonsei Univ, Coll Med, Severance Hosp, Dept Family Med, Seoul, South Korea
[2] Kwandong Univ, Coll Med, Myongji Hosp, Dept Family Med, Goyang, Gyeonggi Do, South Korea
[3] INTOTO Inc, Sport & Med Res Ctr, Seoul, South Korea
来源：
CLINICA CHIMICA ACTA | 2010年 / 411卷 / 23-24期
关键词：
Obesity; Osteocalcin; Visceral obesity; Bone metabolism; Male; POSTMENOPAUSAL WOMEN; ENERGY-METABOLISM; BONE TURNOVER; ELDERLY-WOMEN; WEIGHT-LOSS; MARKERS; GLUCOSE; INSULIN; LEPTIN; MASS;
D O I：
10.1016/j.cca.2010.08.046
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: Growing evidence suggests a link between body composition and serum osteocalcin. Here we examined such an association between serum osteocalcin and body composition in Korean obese men. Methods: Eighty-six men, aged 20 to 76 years, who visited the obesity clinic at the Division of Family Medicine, Severance hospital, Seoul, Korea were recruited for this study. Abdominal fat computed tomography (CT) scans were performed to measure the visceral fat area (VFA) and subcutaneous fat area (SFA). Results: Serum osteocalcin levels were negatively correlated with age, VFA, and vFA/SFA ratio. In addition, serum osteocalcin levels were significantly decreased in obese and overweight subjects with visceral obesity (12.7 +/- 3.2) compared to those without visceral obesity (18.6 +/- 4.9). Multiple regression analysis showed that serum osteocalcin levels were associated with VFA in obese and overweight men after adjustment for age, insulin resistance, current smoking, alcohol consumption and adiposity indices. Conclusion: Osteocalcin was inversely related to visceral obesity in Korean obese and overweight men. These results suggest cross-talk between bone and adipose tissue. (C) 2010 Elsevier By. All rights reserved.
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收藏
页码：2054 / 2057
页数：4
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