New iridoid and phenylethanoid glycosides from the roots of Scrophularia ningpoensis

被引：8

作者：

Liu, Peng ^{[1
]}

Zhou, Meng-Nan ^{[1
]}

Zhu, Lin-Lin ^{[1
]}

Chen, Xiao-He ^{[1
]}

Jiang, Yan-Yan ^{[1
]}

Zhang, Wei ^{[1
]}

Liu, Bin ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China

来源：

TETRAHEDRON | 2021年 / 94卷

基金：

中国国家自然科学基金;

关键词：

Iridoid; Phenylethanoid; Scrophularia ningpoensis; Chemical constituent; Anti-inflammatory;

D O I：

10.1016/j.tet.2021.132325

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new iridoid glycosides, scrophularosides A and B (1-2), two phenylethanoid glycosides, scrophularosides C-D (3-4) and eight known compounds (5-12) were isolated from the roots of Scrophularia ningpoensis. Their structures were elucidated via the interpretation of spectroscopic methods, especially 2D NMR and mass analyses. Compound 1 was a novel iridoid glycoside which possessed a 5/6/7/6 ring system with an unprecedented trioxabicyclo [4.3.1] decane core. The anti-inflammatory potential of new compounds 1-4 was evaluated by determining their ability to inhibit lipopolysaccharide (LPS) induced NO production in RAW 264.7 macrophage cells. (c) 2021 Elsevier Ltd. All rights reserved.

引用

页数：5