Doxorubicin-loaded mesoporous magnetic nanoparticles to induce apoptosis in breast cancer cells

被引：45
作者：
Zou, Yan [1 ,2 ]
Liu, Pin [3 ]
Liu, Chuan-He [4 ]
Zhi, Xu-Ting [5 ]
机构：
[1] Shandong Univ, Dept Gen Surg, Jinan 250100, Shandong, Peoples R China
[2] Heze Municipal Hosp, Dept Gen Surg, Heze 274000, Shandong, Peoples R China
[3] Heze Med Coll, Dept Pathol, Heze 274000, Shandong, Peoples R China
[4] Dingtao Cty Hosp, Dept Internal Med, Heze 274000, Shandong, Peoples R China
[5] Shandong Univ, Qilu Hosp, Dept Gen Surg, Jinan 250012, Shandong, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2015年 / 69卷
关键词：
Magnetic nanoparticles; Doxorubicin; Thermotherapy; Anticancer effect; Breast cancer; DRUG-DELIVERY; CHITOSAN;
D O I：
10.1016/j.biopha.2014.12.012
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Selective targeting of chemotherapeutic drugs toward the cancer cells overcomes the limitations involved in chemotherapy. Ideally, targeted delivery system holds great potential in cancer therapy due to specific release of drug in the cancer tissues. In this regard, DOX-loaded chitosan coated mesoporous magnetic nanoparticles (DOX-CMMN) were prepared and evaluated for its physicochemical and biological characteristics. Nanosized magnetic nanoparticles were observed with a high loading capacity for DOX. The drug-loaded nanoparticles exhibited a controlled and sustained release of drug without any burst release phenomenon. The DOX-DMMN showed a concentration-dependent cell proliferation inhibitory action against breast cancer cells. The blank nanoparticles showed excellent biocompatibility with cell viability >85% at the maximum tested concentration. Our results showed that chitosan coated magnetic system has high potential for breast cancer targeting under an alternating current magnetic field (ACMF). The present study showed that magnetic nanoparticles can be targeted to tumor cells under the presence of oscillating magnetic field. The combined effect of chemotherapy and thermotherapy can have a promising clinical potential for the treatment of breast cancer. (C) 2014 Elsevier Masson SAS. All rights reserved.
引用
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页码：355 / 360
页数：6
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