Clostridioides difficile infection in the Asia-Pacific region

被引：57

作者：

Collins, Deirdre A. ^{[1
]}

Sohn, Kyung Mok ^{[2
]}

Wu, Yuan ^{[3
]}

Ouchi, Kentaro ^{[4
]}

Ishii, Yoshikazu ^{[5
,6
]}

Elliott, Briony ^{[1
]}

Riley, Thomas V. ^{[1
,7
]}

Tateda, Kazuhiro ^{[5
,6
,8
]}

Leung, Michael ^{[9
]}

McGechie, David ^{[10
]}

Keed, Alison ^{[11
]}

Huang, Haihui ^{[12
]}

Liu, Fei ^{[13
]}

Yuan, Yao-Zong ^{[14
]}

Wu, Kaichun ^{[15
]}

Ran, Zhihua ^{[16
]}

Yu, Yunsong ^{[17
]}

Xu, Jinghang ^{[18
]}

Chen, Ye ^{[19
]}

Tsang, Owen Tak Yin ^{[20
]}

Wong, Sunny Hei ^{[21
]}

Hung, Ivan Fan Ngai ^{[22
]}

Madaiah, Srinivasa ^{[23
]}

Yarlagadda, Nagarjuna ^{[24
]}

Abraham, Phillip ^{[25
]}

Gare, Pravin ^{[26
]}

Gasem, Muhammad Hussein ^{[27
]}

Kusachi, Shinya ^{[28
]}

Nagashima, Makoto ^{[29
]}

Park, Soo Jung ^{[30
]}

Kiem, Sungmin ^{[31
]}

Lee, Christopher K. C. ^{[32
]}

Menon, Jayaram ^{[33
]}

Chow, Ting Soo ^{[34
]}

Mendoza, Myrna ^{[35
]}

Mercado, Randy ^{[36
]}

Arguillas, Marilyn ^{[37
]}

Destura, Raul ^{[38
]}

Hui, David Ong Eng ^{[39
]}

Leong, Ang Tiing ^{[40
]}

Lin, Ling Khoon ^{[41
]}

Wu, Yi-Hui ^{[42
]}

Hsueh, Po-Ren ^{[43
]}

Lee, Yuarn-Jang ^{[44
]}

Wang, Jen-Hsien ^{[45
]}

Chen, Yao-Shen ^{[46
]}

Ko, Wen-Chien ^{[47
]}

Kositchaiwat, Chomsri ^{[48
]}

Mahachai, Varocha ^{[49
]}

Chamroonkul, Naichaya ^{[50
]}

机构：

[1] Univ Western Australia, Sch Biomed Sci, Perth, WA, Australia

[2] Chungnam Natl Univ, Dept Internal Med, Sch Med, Div Infect Dis, Daejeon, South Korea

[3] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China

[4] Otsuka Pharmaceut Co Ltd, Med Affairs, Osaka, Japan

[5] Toho Univ, Sch Med, Dept Microbiol & Infect Dis, Tokyo, Japan

[6] Toho Univ, Dept Infect Control, Med Ctr, Omori Hosp, Tokyo, Japan

[7] PathWest Lab Med WA, Dept Microbiol, Perth, WA, Australia

[8] Toho Univ, Med Ctr, Omori Hosp, Lab Microbiol Sect, Tokyo, Japan

[9] PathWest Lab Med WA, Nedlands, WA, Australia

[10] PathWest Lab Med WA, Fremantle, WA, Australia

[11] Royal Perth Hosp, Perth, WA, Australia

[12] Fu Dan Univ, Huasahan Hosp, Shanghai, Peoples R China

[13] Shanghai East Hosp, Shanghai, Peoples R China

[14] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai, Peoples R China

[15] Fourth Mil Med Univ, Xijing Hosp, Xian, Shaanxi, Peoples R China

[16] Shanghai Renji Hosp, Shanghai, Peoples R China

[17] Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Hangzhou, Zhejiang, Peoples R China

[18] Peking Univ First Hosp, Beijing, Peoples R China

[19] Southern Med Univ, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China

[20] Princess Margaret Hosp, Hong Kong, Peoples R China

[21] Princess Margaret Hosp, Shatin, Hong Kong, Peoples R China

[22] Queen Mary Hosp, Pok Fu Lam, Hong Kong, Peoples R China

[23] Mysore Med Coll & Res Inst, Mysore, Karnataka, India

[24] KIMS Hosp, Hyderabad, Andhra Pradesh, India

[25] PD Hinduja Natl Hosp & Med Res Ctr, Mumbai, Maharashtra, India

[26] Chopda Medicare & Res Ctr P Ltd, Magnum Heart Inst, Nasik, India

[27] Rumah Sakit Umum Pusat Dr Kariadi, Semarang, Indonesia

[28] Toho Univ, Med Ctr, Ohashi Hosp, Meguro Ku, Tokyo, Japan

[29] Toho Univ, Med Ctr, Sakura Hosp, Sakura, Chiba, Japan

[30] Yonsei Univ, Severance Hosp, Seoul, South Korea

[31] Inje Univ, Haeundae Paik Hosp, Busan, South Korea

[32] Hosp Sungai Buloh, Sungai Buloh, Selangor, Malaysia

[33] Queen Elizabeth Hosp, CRC, George Town, Malaysia

[34] Hosp Pulau Pinang, George Town, Malaysia

[35] Natl Kidney & Transplant Inst, Quezon City, Philippines

[36] St Lukes Med Ctr, Quezon City, Philippines

[37] Davao Doctors Hosp, Davao, Philippines

[38] Med City, Pasig, Philippines

[39] Natl Univ Singapore Hosp, Singapore, Singapore

[40] Changi Gen Hosp, Singapore, Singapore

[41] Singapore Gen Hosp, Singapore, Singapore

[42] E Da Hosp, Kaohsiung, Taiwan

[43] Natl Taiwan Univ Hosp, Taipei, Taiwan

[44] Taipei Med Univ Hosp, Taipei, Taiwan

[45] China Med Univ Hosp, Taichung, Taiwan

[46] Vet Gen Hosp Kaohsiung, Kaohsiung, Taiwan

[47] Natl Cheng Kung Univ Hosp, Tainan, Taiwan

[48] Ramathibodi Hosp, Bangkok, Krung Thep Maha, Thailand

[49] Chulalongkorn Mem Hosp, Bangkok, Krung Thep Maha, Thailand

[50] Songklanagarind Hosp, Songkhla, Thailand

来源：

EMERGING MICROBES & INFECTIONS | 2020年 / 9卷 / 01期

关键词：

Clostridioides difficile infection; Asia-Pacific; epidemiology; clinical features; molecular epidemiology; MOLECULAR EPIDEMIOLOGY; DOMINANT STRAIN; BINARY TOXIN; EMERGENCE; RESISTANT; PREVALENCE; EVOLUTION; COMMUNITY; PHYLOGENY; DIAGNOSIS;

D O I：

10.1080/22221751.2019.1702480

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clostridioides difficile causes healthcare-related diarrhoea in high-income countries. Highly resistant spores persist in healthcare facilities, primarily infecting patients who have recently received antimicrobials. C. difficile infection (CDI) has been studied in detail in North America and Europe; however, the epidemiology of CDI elsewhere, including the Asia-Pacific region, is largely unknown. A survey of CDI was performed in 13 Asia-Pacific countries. Epidemiological data on 600 cases were collected and molecular typing undertaken on 414 C. difficile isolates. Healthcare facility-associated CDI comprised 53.6% of cases, while community-associated CDI was 16.5%. The median age of cases was 63.0 years and 45.3% were female, 77.5% had used antibiotics in the previous 8 weeks, most frequently third-generation cephalosporins (31.7%), and 47.3% had used proton pump inhibitors. Recurrence (9.1%) and mortality (5.2%) rates were low, while complications including colitis or pseudomembranous colitis (13.8%), colectomy (0.4%), and toxic megacolon (0.2%) were uncommon. Common C. difficile strains were ribotypes 017 (16.7%), 014/020 (11.1%) and 018 (9.9%), with wide variation between countries. Binary toxin-positive strains of C. difficile were detected rarely. Overall, disease severity appeared mild, and mortality and recurrence were low. Continued education about, and surveillance of, CDI in Asia are required to reduce the burden of disease.

引用

页码：42 / 52

页数：11

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