NEUTROPHIL PARALYSIS IN SEPSIS

被引：165
作者：
Alves-Filho, Jose C. [1 ]
Spiller, Fernando [1 ]
Cunha, Fernando Q. [1 ]
机构：
[1] Univ Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil
来源：
SHOCK | 2010年 / 34卷
关键词：
Sepsis; neutrophil; chemotaxis; nitric oxide; Toll-like receptors; ENDOTHELIAL-CELL-INTERACTIONS; HEME OXYGENASE-1 INDUCTION; INDUCIBLE NITRIC-OXIDE; TUMOR-NECROSIS-FACTOR; POLYMICROBIAL SEPSIS; LEUKOCYTE MIGRATION; CRUCIAL ROLE; TNF-ALPHA; EXPRESSION; RECEPTOR;
D O I：
10.1097/SHK.0b013e3181e7e61b
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Sepsis develops when the initial host response is unable to contain the primary infection, resulting in widespread inflammation and multiple organ dysfunction. The impairment of neutrophil migration into the infection site, also termed neutrophil paralysis, is a critical hallmark of sepsis, which is directly related to the severity of the disease. Although the precise mechanism of this phenomenon is not fully understood, there has been much advancement in the understanding of this field. In this review, we highlight the recent insights into the molecular mechanisms of neutrophil paralysis during sepsis.
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页码：15 / 21
页数：7
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