Medical radioisotope 89Zr production with RFT-30 cyclotron

被引：4

作者：

Lee, Jun Young ^{[1
]}

Hur, Min Goo ^{[1
]}

Kong, Young Bae ^{[1
]}

Lee, Eun Je ^{[1
]}

Yang, Seung Dae ^{[1
]}

Choi, Pyeong Seok ^{[1
]}

Park, Jeong Hoon ^{[1
]}

机构：

[1] Korea Atom Energy Res Inst, Accelerator Radioisotope Dev Team, 29 Geumgu Gil, Jeongeup So 56212, Jeollabuk Do, South Korea

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2021年 / 330卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

RFT-30 MeV cyclotron; (89)Zirconium; Positron emission tomography; Radionuclide; Radiochemical separation; EXCITATION-FUNCTIONS; THRESHOLD;

D O I：

10.1007/s10967-021-07884-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Zr-89 is an emerging radionuclide with promising application in nuclear medicine for the non-invasive diagnosis of various cancers with PET imaging. This paper would discuss optimization efforts in the production of Zr-89 carried out at Accelerator Radioisotope Development Team, Korea Atomic Energy Research Institute. Optimized conditions reveal high production yields of Zr-89 similar to 37 +/- 1.4 MBq/mu A using Y-89(p,n)Zr-89, similar to 12.7 MeV of proton, and 35 mu A using yttrium coin target with indigenously constructed 30 MeV Cyclotron (RFT-30). Besides, the production optimization, quality control, and biological behavior of [Zr-89]Zr-oxalate, chloride and, DFO demonstrated promising results.

引用

页码：455 / 460

页数：6

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