Critical roles of non-histone protein lysine methylation in human tumorigenesis

被引：298

作者：

Hamamoto, Ryuji ^{[1
]}

Saloura, Vassiliki ^{[1
]}

Nakamura, Yusuke ^{[1
]}

机构：

[1] Univ Chicago, Hematol Oncol Sect, Dept Med, Chicago, IL 60637 USA

来源：

NATURE REVIEWS CANCER | 2015年 / 15卷 / 02期

关键词：

NF-KAPPA-B; ACUTE MYELOID-LEUKEMIA; TUMOR-SUPPRESSOR GENE; RENAL-CELL CARCINOMA; HISTONE METHYLTRANSFERASE EZH2; ACUTE LYMPHOBLASTIC-LEUKEMIA; DOMAIN-CONTAINING PROTEIN; GROWTH-FACTOR RECEPTOR-1; COLORECTAL-CANCER CELLS; NON-HODGKIN-LYMPHOMA;

D O I：

10.1038/nrc3884

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several protein lysine methyltransferases and demethylases have been identified to have critical roles in histone modification. A large body of evidence has indicated that their dysregulation is involved in the development and progression of various diseases, including cancer, and these enzymes are now considered to be potential therapeutic targets. Although most studies have focused on histone methylation, many reports have revealed that these enzymes also regulate the methylation dynamics of non-histone proteins such as p53, RB1 and STAT3 (signal transducer and activator of transcription 3), which have important roles in human tumorigenesis. In this Review, we summarize the molecular functions of protein lysine methylation and its involvement in human cancer, with a particular focus on lysine methylation of non-histone proteins.

引用

页码：110 / 124

页数：15

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