A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery

被引：112
作者：
Lahiji, Shayan F. [1 ]
Dangol, Manita [1 ]
Jung, Hyungil [1 ]
机构：
[1] Yonsei Univ, Dept Biotechnol, Seoul 120749, South Korea
来源：
SCIENTIFIC REPORTS | 2015年 / 5卷
关键词：
FREE JET INJECTION; DRAWING LITHOGRAPHY; PATCHES; SKIN; INSULIN; FORCE;
D O I：
10.1038/srep07914
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are superimposed onto patches that facilitate their insertion into skin. However, due to wide variations in skin elasticity and the amount of hair on the skin, the arrays fabricated on the patch are often not completely inserted and large amount of loaded materials are not delivered. Here, we report "Microlancer'', a novel micropillar based system by which patients can self-administer DMNs and which would also be capable of achieving 97 +/- 2% delivery efficiency of the loaded drugs regardless of skin type or the amount of hair on the skin in less than a second.
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页数：7
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