Antitumor polysaccharides from mushrooms: a review on the structural characteristics, antitumor mechanisms and immunomodulating activities

被引：388

作者：

Meng, Xin ^{[1
]}

Liang, Hebin ^{[1
]}

Luo, Lixin ^{[1
]}

机构：

[1] S China Univ Technol, Sch Biosci & Bioengn, Guangzhou 510006, Guangdong, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2016年 / 424卷

基金：

中国国家自然科学基金;

关键词：

Mushroom polysaccharide; Folk medicine; Antitumor; Mechanism; PROTEIN-BOUND POLYSACCHARIDE; BETA-D-GLUCAN; WATER-SOLUBLE EXTRACT; PORIA-COCOS MYCELIA; CELL-CYCLE ARREST; REI-SHI MYCELIA; GANODERMA-LUCIDUM EXTRACT; NITRIC-OXIDE PRODUCTION; NF-KAPPA-B; FRUITING BODIES;

D O I：

10.1016/j.carres.2016.02.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mushrooms are popular folk medicines that have attracted considerable attention because of their efficient antitumor activities. This review covers existing research achievements on the mechanisms of isolated mushroom polysaccharides, particularly (1 -> 3)-beta-D-glucans. Our review also describes the function in modulating the immune system and potential tumor-inhibitory effects of polysaccharides. The antitumor mechanisms of mushroom polysaccharides are mediated by stimulated T cells or other immune cells. These polysaccharides are able to trigger various cellular responses, such as the expression of cytokines and nitric oxide. Most polysaccharides could bind other conjugate molecules, such as polypeptides and proteins, whose conjugation always possess strong antitumor activities. The purpose of this review is to summarize available information, and to reflect the present situation of polysaccharide research filed with a view for future direction. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：30 / 41

页数：12

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