Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice

被引：20
|
作者：
Zhang, Yizi [1 ]
Sun, Lingli [2 ]
Lai, Xingfei [2 ]
Peng, Xingjia [1 ]
Wen, Shuai [2 ]
Zhang, Zhenbiao [2 ]
Xie, Yinzheng [1 ]
Li, Qiuhua [2 ]
Chen, Ruohong [2 ]
Zheng, Xi [1 ]
Zhang, Kun [1 ]
Sun, Shili [2 ]
Li, Dongli [1 ,3 ]
机构：
[1] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China
[2] Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Key Lab Tea Resources Innovat & Utiliza, Guangzhou 510640, Peoples R China
[3] Int Healthcare Innovat Inst Jiangmen, Jiangmen 529040, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 144卷
基金：
中国国家自然科学基金;
关键词：
Inflammation; Oxidative stress; Gastrointestinal mucosal damage; Apoptosis; OXIDATIVE STRESS; NITRIC-OXIDE; IN-VITRO; LIPID-PEROXIDATION; FREE-RADICALS; ANTIOXIDANT; LESIONS; DAMAGE; PROSTAGLANDINS; MECHANISM;
D O I：
10.1016/j.biopha.2021.112268
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Jasminum grandiflorum L. is a medicinal plant used to treat hepatitis and gastritis, but the mechanisms underlying its protective effects against gastrointestinal mucosal damage remain to be elucidated. In this study, we analyzed the effects of four different extracts and two compounds from the flower of J. grandiflorum in a mouse model of HCl/EtOH-induced gastric ulcer. The flower extracts alleviated gastric mucosal ulceration by increasing PGE2 production and the activity of antioxidant enzymes, along with the suppression of reactive oxygen species (ROS) generation, lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines and nitric oxide (NO) production.
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页数：13
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