Mucoadhesive and pH-responsive behavior of gelatin containing hydrogels for protein drug delivery applications

被引：21

作者：

Oh, Jihwan ^{[1
]}

Kim, Bumsang ^{[1
]}

机构：

[1] Hongik Univ, Dept Chem Engn, Seoul 04066, South Korea

来源：

KOREA-AUSTRALIA RHEOLOGY JOURNAL | 2020年 / 32卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

poly(acrylic acid); gelatin; pH-sensitive copolymers; mucoadhesive hydrogels; oral drug delivery; DOUBLE-NETWORK HYDROGELS; MECHANICAL-PROPERTIES; COPOLYMERS;

D O I：

10.1007/s13367-020-0005-6

中图分类号：

O3 [力学];

学科分类号：

08 ; 0801 ;

摘要：

Novel gelatin-containing polymer hydrogels that can be used as mucoadhesive delivery systems were developed. Poly(acrylic acid) hydrogels were modified by copolymerizing gelatin as adhesion promoter, to improve the adhesion to the mucus layer and the synthesized copolymer of acrylic acid (AA) and methacrylated gelatin (GelMA) were designated as P(AA-co-GelMA). The pH-sensitivity and the mucoadhesive property of the P(AA-co-GelMA) hydrogel were investigated as carries of an oral protein delivery system activated by pH changes of the human GI tract. There was a drastic change in the weight swelling ratio of P(AA-co-GelMA) hydrogels at a pH of around 5, that is, low swelling ratios at a pH below 5, while high swelling ratios at a pH greater than 5. In addition, the swelling ratio increased at a pH above 5, when the AA content in the hydrogel increased. In mucoadhesive experiments using the rheometer, when the GelMA concentration in the P(AA-co-GelMA) hydrogel increased, the maximum force of detachment increased, indicating that the mucoadhesion of the hydrogel was improved. The P(AA-co-GelMA) hydrogels also showed a pH-responsive release behavior. The ratio of the cumulative amounts of Rh-B released from P(AA-co-GelMA) hydrogels at pH 2.6 to pH 7.0 increased, when the AA content in the hydrogel decreased.

引用

页码：41 / 46

页数：6

共 26 条

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