Reversal of multidrug resistance (MDR) by aspidofractinine-type indole alkaloids

被引：52

作者：

Kam, TS ^{[1
]}

Subramaniam, G

Sim, KM

Yoganathan, K

Koyano, T

Toyoshima, M

Rho, MC

Hayashi, M

Komiyama, K

机构：

[1] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia

[2] Temko Corp, Nakano Ku, Tokyo 164, Japan

[3] Kitasato Inst, Minato Ku, Tokyo 1088642, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(98)00486-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of indole alkaloids of the aspidofractinine-type was assessed for their potential in reversing MDR in vincristine-resistant KB cells. Of the compounds tested, kopsiflorine, kopsamine, pleiocarpine, 11-methoxykopsliongine, lahadinine A and N-methoxycarbonyl-11,12-methylenedioxy-Delta(16,17)-kopsinine were found to show appreciable activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2769 / 2772

页数：4

共 22 条

[1] ALKALOIDS OF KOPSIA SPECIES .1. KOPSINE, FRUTICOSAMINE, AND FRUTICOSINE [J].