Suppressor of cytokine signaling (SOCS) genes are downregulated in breast cancer

被引：43
作者：
Ghafouri-Fard, Soudeh [1 ]
Oskooei, Vahid Kholghi [1 ]
Azari, Iman [1 ]
Taheri, Mohammad [2 ,3 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Dept Med Genet, POB 19857-17443, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Student Res Comm, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran, Iran
来源：
WORLD JOURNAL OF SURGICAL ONCOLOGY | 2018年 / 16卷
关键词：
Suppressor of cytokine signaling; Breast cancer; Expression; TUMOR-SUPPRESSOR; EXPRESSION; CELLS;
D O I：
10.1186/s12957-018-1529-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BackgroundThe suppressor of cytokine signaling (SOCS) family of proteins are inhibitors of the cytokine-activated Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. We aimed at evaluation of expression of SOCS genes in breast cancer.MethodsWe evaluated expression of SOCS1-3 and SOCS5 genes in breast cancer samples compared with the corresponding adjacent non-cancerous tissues (ANCTs).ResultsAll assessed SOCS genes were significantly downregulated in tumoral tissues compared with ANCTs. SOCS1 and SOCS2 genes were significantly overexpressed in higher grade samples, but SOCS3 had the opposite trend. Significant correlations were found between expression levels of SOCS genes. The SOCS1 and SOCS2 expression levels had the best specificity and sensitivity values respectively for breast cancer diagnosis.ConclusionThe current study provides further evidence for contribution of SOCS genes in breast cancer.
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页数：9
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