Musculoskeletal manifestations and autoantibody profile in 90 hepatitis C virus infected Israeli patients

被引:94
作者
Buskila, D
Shnaider, A
Neumann, L
Lorber, M
Zilberman, D
Hilzenrat, N
Kuperman, OJ
Sikuler, E
机构
[1] Soroka Med Ctr, Dept Med B, Rheumat Dis Unit, IL-84101 Beer Sheva, Israel
[2] Soroka Med Ctr, Dept Epidemiol, Beer Sheva, Israel
[3] Rambam Med Ctr, Div Immunol, Haifa, Israel
[4] Ben Gurion Univ Negev, Dept Epidemiol, IL-84105 Beer Sheva, Israel
[5] Rambam Med Ctr, Div Immunol, Haifa, Israel
[6] Soroka Med Ctr, Clin Immunol Lab, IL-84101 Beer Sheva, Israel
关键词
hepatitis C virus; musculoskeletal manifestations; rheumatic disease; autoantibodies;
D O I
10.1016/S0049-0172(98)80043-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: Recent interest has been expressed in rheumatic manifestations in hepatitis C virus (HCV)-infected populations, The aim of this study was to determine the prevalence and characteristics of the musculoskeletal manifestations and serological markers of autoimmunity in HCV-infected patients in Israel. Methods: Ninety anti-HCV-positive patients were consecutively interviewed and examined. The prevalence of autoantibodies and their association with rheumatologic symptoms were also determined. Results: Rheumatic manifestations were found in 28 subjects (31%), and included arthralgias (9%), arthritis (4%), cryoglobulinemia (11%), sicca symptoms (8%), cutaneous vasculitis (2%), polymyositis (1%), and antiphospholipid syndrome (1%). Rheumatic complications were not associated with liver disease severity, or subjects' gender. In addition, myalgia was reported by 22 patients (24%), and fibromyalgia was diagnosed in 14 (16%). Sixty-nine percent of the patients had at least one autoantibody detected in their serum, the most prevalent being rheumatoid factor (RF), 44%; antinuclear antibody (ANA), 38%; and IgM and IgG anticardiolipin antibodies (acl), 28% and 22%, respectively. The frequency of autoantibodies was not associated with liver disease severity or rheumatic disorders. Conclusions: Musculoskeletal manifestations and autoimmune markers are common in HCV infection. An investigation of risk factors for HCV infection is pertinent in a patient presenting new rheumatic manifestations and should be included in the history of present illness. Future studies of these disorders may uncover the full spectrum of these associations and provide new insights into their operating mechanisms. Copyright (C) 1998 by W.B. Saunders Company.
引用
收藏
页码:107 / 113
页数:7
相关论文
共 45 条
[1]   Hepatitis B and C viruses serology in patients with SLE [J].
AbuShakra, M ;
ElSana, S ;
Margalith, M ;
Sikuler, E ;
Neumann, L ;
Buskila, D .
LUPUS, 1997, 6 (06) :543-544
[2]   THE ETIOLOGY OF MIXED CRYOGLOBULINEMIA ASSOCIATED WITH HEPATITIS-C VIRUS-INFECTION [J].
AGNELLO, V .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1995, 42 (02) :179-184
[3]   A ROLE FOR HEPATITIS-C VIRUS-INFECTION IN TYPE-II CRYOGLOBULINEMIA [J].
AGNELLO, V ;
CHUNG, RT ;
KAPLAN, LM .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (21) :1490-1495
[4]   COMMUNITY-ACQUIRED VIRAL HEPATITIS-B AND HEPATITIS-C IN THE UNITED-STATES [J].
ALTER, MJ .
GUT, 1993, 34 (02) :S17-S19
[5]   Fibromyalgia in hepatitis C virus infection - Another infectious disease relationship [J].
Buskila, D ;
Shnaider, A ;
Neumann, L ;
Zilberman, D ;
Hilzenrat, N ;
Sikuler, E .
ARCHIVES OF INTERNAL MEDICINE, 1997, 157 (21) :2497-2500
[6]   MIXED CRYOGLOBULINEMIA AND HEPATITIS-C VIRUS [J].
CACOUB, P ;
FABIANI, FL ;
MUSSET, L ;
PERRIN, M ;
FRANGEUL, L ;
LEGER, JM ;
HURAUX, JM ;
PIETTE, JC ;
GODEAU, P .
AMERICAN JOURNAL OF MEDICINE, 1994, 96 (02) :124-132
[7]   ISOLATION OF A CDNA CLONE DERIVED FROM A BLOOD-BORNE NON-A, NON-B VIRAL-HEPATITIS GENOME [J].
CHOO, QL ;
KUO, G ;
WEINER, AJ ;
OVERBY, LR ;
BRADLEY, DW ;
HOUGHTON, M .
SCIENCE, 1989, 244 (4902) :359-362
[8]   HIGH PREVALENCE OF SEROLOGICAL MARKERS OF AUTOIMMUNITY IN PATIENTS WITH CHRONIC HEPATITIS-C [J].
CLIFFORD, BD ;
DONAHUE, D ;
SMITH, L ;
CABLE, E ;
LUTTIG, B ;
MANNS, M ;
BONKOVSKY, HL .
HEPATOLOGY, 1995, 21 (03) :613-619
[9]   SJOGRENS-SYNDROME AND HEPATITIS-C VIRUS-INFECTION [J].
DURAND, JM ;
LEFEVRE, P ;
KAPLANSKI, G ;
RETORNAZ, F ;
CRETEL, E ;
CHAUSSEGROS, C ;
TREPO, C ;
SOUBEYRAND, J .
CLINICAL RHEUMATOLOGY, 1995, 14 (05) :570-571
[10]   CUTANEOUS VASCULITIS IN A PATIENT INFECTED WITH HEPATITIS-C VIRUS - DETECTION OF HEPATITIS-C VIRUS-RNA IN THE SKIN BY POLYMERASE CHAIN-REACTION [J].
DURAND, JM ;
KAPLANSKI, G ;
RICHARD, MA ;
LEFEVRE, P ;
QUILES, N ;
TREPO, C ;
SOUBEYRAND, J .
BRITISH JOURNAL OF DERMATOLOGY, 1993, 128 (03) :359-360