Immune Checkpoint Inhibitors and Kidney Toxicity: Advances in Diagnosis and Management

被引:38
作者
Seethapathy, Harish [1 ]
Herrmann, Sandra M. [2 ]
Sise, Meghan E. [1 ]
机构
[1] Massachusetts Gen Hosp, Dept Internal Med, Div Nephrol, Boston, MA 02114 USA
[2] Mayo Clin, Dept Internal Med, Div Nephrol & Hypertens, Rochester, MN USA
关键词
INTERSTITIAL NEPHRITIS; CLINICAL-FEATURES; CANCER; THERAPY; INJURY; IMMUNOTHERAPY; MELANOMA; RISK; ANTI;
D O I
10.1016/j.xkme.2021.08.008
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Immune checkpoint inhibitors are now approved for more than 50 indications, and increasing numbers of patients with advanced cancer are receiving immunotherapy. Immune-related adverse events that result from checkpoint inhibitors can affect any organ system. The most common kidney side effect is acute kidney injury, typically caused by acute interstitial nephritis. This review covers the most recent advances in immune checkpoint inhibitor-induced acute kidney injury. The review focuses on the differences between checkpoint inhibitor classes in causing acute kidney injury and differentiating immune checkpoint inhibitor-induced kidney damage from other causes of acute kidney injury. We describe the appropriate use of a kidney biopsy in the diagnosis of acute kidney injury and highlight the need for identification of noninvasive diagnostic and predictive biomarkers of immune checkpoint inhibitor-induced acute kidney injury. In the treatment section, approaches to corticosteroid use and the risks and benefits of rechallenging patients who experience acute kidney injury are debated. We also clarify the long-term adverse effects of immune checkpoint inhibitors on kidney function and the risk of chronic kidney disease in cancer survivors. (C) 2021 The Authors. Published by Elsevier Inc. on behalf of the National Kidney Foundation, Inc.
引用
收藏
页码:1074 / 1081
页数:8
相关论文
共 63 条
[1]  
Abdel-Wahab N, 2018, ANN INTERN MED, V169, P133, DOI 10.7326/L18-0209
[2]   Immune checkpoint inhibitors of PD-L1 as cancer therapeutics [J].
Akinleye, Akintunde ;
Rasool, Zoaib .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2019, 12 (01)
[3]  
[Anonymous], Timeline of progress.
[4]  
[Anonymous], COMMON TERMINOLOGY C
[5]   Cancer and Mortality in Solid-Organ Transplantation: Preventable or Inevitable? [J].
Asch, William S. ;
Perazella, Mark A. .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2016, 68 (06) :839-842
[6]  
Atiq SO, J ONCO NEPHROLOGY, V5, P23
[7]   Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis [J].
Baxi, Shrujal ;
Yang, Annie ;
Gennarelli, Renee L. ;
Khan, Niloufer ;
Wang, Ziwei ;
Boyce, Lindsay ;
Korenstein, Deborah .
BMJ-BRITISH MEDICAL JOURNAL, 2018, 360
[8]   Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline [J].
Brahmer, Julie R. ;
Lacchetti, Christina ;
Schneider, Bryan J. ;
Atkins, Michael B. ;
Brassil, Kelly J. ;
Caterino, Jeffrey M. ;
Chau, Ian ;
Ernstoff, Marc S. ;
Gardner, Jennifer M. ;
Ginex, Pamela ;
Hallmeyer, Sigrun ;
Chakrabarty, Jennifer Holter ;
Leighl, Natasha B. ;
Mammen, Jennifer S. ;
McDermott, David F. ;
Naing, Aung ;
Nastoupil, Loretta J. ;
Phillips, Tanyanika ;
Porter, Laura D. ;
Puzanov, Igor ;
Reichner, Cristina A. ;
Santomasso, Bianca D. ;
Seigel, Carole ;
Spira, Alexander ;
Suarez-Almazor, Maria E. ;
Wang, Yinghong ;
Weber, Jeffrey S. ;
Wolchok, Jedd D. ;
Thompson, John A. .
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (17) :1714-+
[9]   Anti - PD-1 Immunotherapy May Induce Interstitial Nephritis With Increased Tubular Epithelial Expression of PD-L1 [J].
Cassol, Clarissa ;
Satoskar, Anjali ;
Lozanski, Gerard ;
Rovin, Brad ;
Hebert, Lee ;
Nadasdy, Tibor ;
Brodsky, Sergey, V .
KIDNEY INTERNATIONAL REPORTS, 2019, 4 (08) :1152-1160
[10]   Incidence and Predictors of CKD and Estimated GFR Decline in Patients Receiving Immune Checkpoint Inhibitors [J].
Chute, Donald F. ;
Zhao, Sophia ;
Strohbehn, Ian A. ;
Rusibamayila, Nifasha ;
Seethapathy, Harish ;
Lee, Meghan ;
Zubiri, Leyre ;
Gupta, Shruti ;
Leaf, David E. ;
Rahma, Osama ;
Drobni, Zsofia D. ;
Neilan, Tomas G. ;
Reynolds, Kerry L. ;
Sise, Meghan E. .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2022, 79 (01) :134-137