Self-assembled micelles based on hydrophobically modified quaternized cellulose for drug delivery

被引：100

作者：

Song, Yongbo ^{[1
]}

Zhang, Lingzhi ^{[1
]}

Gan, Weiping ^{[1
]}

Zhou, Jinping ^{[1
]}

Zhang, Lina ^{[1
]}

机构：

[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2011年 / 83卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Self-assembly; Micelles; Amphiphilic; Cellulose; Drug delivery; SULFATE CHITOSAN MICELLES; POLYMERIC MICELLES; GLYCOL CHITOSAN; NANOPARTICLES; CARRIERS; RELEASE; SYSTEMS; SOLUBILIZATION; DERIVATIVES; PACLITAXEL;

D O I：

10.1016/j.colsurfb.2010.11.039

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Novel amphiphilic cationic cellulose (HMQC) derivatives carrying long chain alkyl groups as hydrophobic moieties and quaternary ammonium groups as hydrophilic moieties were synthesized. Structure and properties of the amphiphilic cellulose derivatives were characterized by elemental analysis. FT-IR, H-1 NMR, zeta-potential measurement, dynamic light scattering (DLS), fluorescence spectroscopy and transmission electron microscopy (TEM). The results revealed that HMQCs can be self-assembled into cationic micelles in distilled water with the average hydrodynamic radius of 320-430 nm. The cytotoxicity study showed that the HMQC exhibited low cytotoxicity. Prednisone acetate, a water insoluble anti-inflammation drug, was chosen as a model drug to investigate the utilization of self-assembled HMQC micelles as a delivery carrier for poorly water-soluble drugs. The study indicated that the prednisone acetate could be incorporated effectively in the self-assembled HMQC micelles and be controlled released. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：313 / 320

页数：8

共 39 条

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