Evaluation of Maternal Exposure to Multiple Trace Elements and Their Detection in Umbilical Cord Blood

被引:1
作者
Stojsavljevic, Aleksandar [1 ,2 ]
Rovcanin, Marija [3 ,4 ]
Jagodic, Jovana [1 ]
Mikovic, Zeljko [3 ,4 ]
Jeremic, Ana [3 ]
Perovic, Milan [3 ,4 ]
Manojlovic, Dragan [1 ,5 ]
机构
[1] Univ Belgrade, Fac Chem, Studentski Trg 12-16, Belgrade, Serbia
[2] Univ Belgrade, Innovat Ctr, Fac Chem, Studentski Trg 12-16, Belgrade 11000, Serbia
[3] Clin Gynecol & Obstet Narodni Front, Kraljice Natalije 62, Belgrade, Serbia
[4] Univ Belgrade, Fac Med, Dr Subotica Starijeg 8, Belgrade, Serbia
[5] South Ural State Univ, Lenin Prospect 76, Chelyabinsk, Russia
关键词
Trace element; Umbilical cord blood plasma; Reference values (RVs); Pregnancy and health; MERCURY; PLACENTA; SERUM; LEAD; PREGNANCY; SELENIUM; CADMIUM; SAMPLES;
D O I
10.1007/s12403-021-00441-5
中图分类号
TV21 [水资源调查与水利规划];
学科分类号
081501 ;
摘要
Due to the recognized harmful effects of some trace elements on fetal development after long-term exposures, it is first important to address their basic/physiological levels before monitoring toxicological effects and clinical outcomes on prenatal and postnatal health. This research aimed to define, for the first time, reference values for multiple (ultra) trace elements in umbilical cord blood (UCB) plasma samples of a notable number of healthy pregnant women (n = 125). All samples were collected during 2020-2021 and all participants were from Belgrade and two regions (Sumadija and Podunavlje). Following trace elements were enrolled in this study: essential (Mn, Co, Cu, Zn, Se, Mo), toxic (Be, Al, Ni, As, Rb, Sr, Ag, Cd, Sb, Ba, Tl, Pb, Th, U), rare earth (La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm), and noble metals (Ru, Rh, Pd, Re, Ir, Os, Pt). UCB plasma samples were diluted with suitable solvents and analyzed by inductively coupled plasma-mass spectrometry. The analytical technique used was validated by the standard addition method and using certified reference materials. Zn was found in the highest amount and Tm in the least amount. Be, Co, Ag, Sb, La, and Ce exhibited statistically significant differences in the four age groups (20 to 41 years), whereas Ag and Ce showed a tendency to increase with age. Furthermore, our participants had notably higher As, Ni, and Co, levels and lower Zn levels compared to other populations. This is the first study that, in addition to analyzing essential and toxic trace elements, also provided an analysis of noble and rare earth elements in UCB plasma samples. Presented results can be used as a starting point or database for further studies, in terms of predicting the pregnancy outcome and postnatal development.
引用
收藏
页码:623 / 633
页数:11
相关论文
共 48 条
[1]   Effect of Adding Cerium on Microstructure and Morphology of Ce-Based Inclusions Formed in Low-Carbon Steel [J].
Adabavazeh, Z. ;
Hwang, W. S. ;
Su, Y. H. .
SCIENTIFIC REPORTS, 2017, 7
[2]   Arsenic-Associated Oxidative Stress, Inflammation, and Immune Disruption in Human Placenta and Cord Blood [J].
Ahmed, Sultan ;
Khoda, Sultana Mahabbat-e ;
Rekha, Rokeya Sultana ;
Gardner, Renee M. ;
Ameer, Syeda Shegufta ;
Moore, Sophie ;
Ekstrom, Eva-Charlotte ;
Vahter, Marie ;
Raqib, Rubhana .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2011, 119 (02) :258-264
[3]   Birth outcome measures and maternal exposure to heavy metals (lead, cadmium and mercury) in Saudi Arabian population [J].
Al-Saleh, Iman ;
Shinwari, Neptune ;
Mashhour, Abdullah ;
Rabah, Abdullah .
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2014, 217 (2-3) :205-218
[4]   Urinary Concentrations of Metals and Metalloids in Malaysian Adults [J].
Anual, Zurahanim Fasha ;
Sham, Noraishah Mohammad ;
Ambak, Rashidah ;
Othman, Fatimah ;
Shaharudin, Rafiza .
EXPOSURE AND HEALTH, 2021, 13 (03) :391-401
[5]   Assessment of ten trace elements in umbilical cord blood and maternal blood: association with birth weight [J].
Bermudez, Lorena ;
Garcia-Vicent, Consuelo ;
Lopez, Jorge ;
Isabel Torro, Maria ;
Lurbe, Empar .
JOURNAL OF TRANSLATIONAL MEDICINE, 2015, 13
[6]   Human biomonitoring to evaluate exposure to toxic and essential trace elements during pregnancy. Part B: Predictors of exposure [J].
Bocca, Beatrice ;
Ruggieri, Flavia ;
Pino, Anna ;
Rovira, Joaquim ;
Calamandrei, Gemma ;
Mirabella, Fiorino ;
Angeles Martinez, Maria ;
Domingo, Jose L. ;
Alimonti, Alessandro ;
Schuhmacher, Marta .
ENVIRONMENTAL RESEARCH, 2020, 182
[7]   Human biomonitoring to evaluate exposure to toxic and essential trace elements during pregnancy. Part A. concentrations in maternal blood, urine and cord blood [J].
Bocca, Beatrice ;
Ruggieri, Flavia ;
Pino, Anna ;
Rovira, Joaquim ;
Calamandrei, Gemma ;
Angeles Martinez, Maria ;
Domingo, Jose L. ;
Alimonti, Alessandro ;
Schuhmacher, Marta .
ENVIRONMENTAL RESEARCH, 2019, 177
[8]  
Burtis CarlA., 2012, Textbook of clinical chemistry and molecular diagnostics -TIETZ, V5th
[9]   Human Health Risk Assessment Due to Agricultural Activities and Crop Consumption in the Surroundings of an Industrial Area [J].
Cabral-Pinto, Marina M. S. ;
Inacio, Manuela ;
Neves, Orquidia ;
Almeida, Agostinho A. ;
Pinto, Edgar ;
Oliveiros, Barbara ;
Ferreira da Silva, Eduardo A. .
EXPOSURE AND HEALTH, 2020, 12 (04) :629-640
[10]   Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic in utero [J].
Cardenas, Andres ;
Koestler, Devin C. ;
Houseman, E. Andres ;
Jackson, Brian P. ;
Kile, Molly L. ;
Karagas, Margaret R. ;
Marsit, Carmen J. .
EPIGENETICS, 2015, 10 (06) :508-515