Copper-catalyzed base-accelerated direct oxidation of C-H bond to synthesize benzils, isatins, and quinoxalines with molecular oxygen as terminal oxidant

被引：50

作者：

Yu, Jing-Wen ^{[1
]}

Mao, Shuai ^{[1
]}

Wang, Yong-Qiang ^{[1
]}

机构：

[1] NW Univ Xian, Dept Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Peoples R China

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Synthetic methods; Oxidation; Radical reactions; Copper; Benzils; ONE-POT SYNTHESIS; STRUCTURE-BASED DESIGN; ROOM-TEMPERATURE; UNSYMMETRICAL BENZILS; BENZOIN CONDENSATION; ORGANIC SENSITIZERS; HIGHLY EFFICIENT; SOLAR-CELLS; METAL-FREE; 1,2-DIKETONES;

D O I：

10.1016/j.tetlet.2015.02.019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe herein an efficient and general copper (II)-catalyzed base-accelerated oxidation of the C-H bond to synthesize benzils and isatins. With similar oxidation system an efficient one-pot procedure for the synthesis of quinoxaline derivatives was realized. The two protocols feature using molecular oxygen as terminal oxidant, low catalyst loading, wide substrate scope, and high functional-group tolerance. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：1575 / 1580

页数：6

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