Treatment of Colorectal Cancer with Unresectable Synchronous Liver-Only Metastases with Combined Therapeutic Modalities

被引：5
作者：
Cui, Yunlong [1 ]
Li, Huikai [1 ]
Wu, Qiang [1 ]
Zhang, Ti [1 ]
Kong, Dalu [1 ]
Song, Tianqiang [1 ]
Ru, Tao [1 ]
Chen, Ping [1 ]
Li, Qiang [1 ]
机构：
[1] Tianjin Med Univ, Canc Inst & Hosp, Dept Hepatobiliary Surg, Tianjin, Peoples R China
来源：
JOURNAL OF GASTROINTESTINAL SURGERY | 2011年 / 15卷 / 02期
关键词：
Colorectal cancer; Liver metastases; Radiofrequency ablation; Hepatic artery infusion; Systemic chemotherapy; HEPATIC ARTERIAL INFUSION; RADIOFREQUENCY ABLATION; RESECTION; CHEMOTHERAPY; OXALIPLATIN; RECURRENCE; SURVIVAL; INTRAARTERIAL; TRIAL;
D O I：
10.1007/s11605-010-1357-x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Resection + radiofrequency ablation (RFA) + hepatic artery infusion (HAI) + systemic chemotherapy for patients with unresectable synchronous liver-only metastases from colorectal cancer was rarely used previously. We compared the outcomes of 42 patients underwent resection + RFA + HAI + systemic chemotherapy (RRHS) with that of 43 patients underwent resection + RFA + systemic chemotherapy (RRS). The overall survival, the survival free of hepatic recurrence and the median survival in the RRHS group were all significantly higher than those in RRS group at 4 years. While the rates of adverse effects were similar in the two groups. For patients with unresectable synchronous liver-only metastases from colorectal cancer, RRHS not only decreases but also postpones hepatic recurrence and therefore improves overall survival at 4 years, as compared with RRS.
引用
收藏
页码：285 / 293
页数：9
相关论文
共 19 条
  • [1] Abdalla EK, 2004, ANN SURG, V239, P818, DOI 10.1097/01.sla.0000128305.90650.71
  • [2] Hepatic arterial infusion of oxaliplatin and intravenous LV5FU2 in unresectable liver metastases from colorectal cancer after systemic chemotherapy failure
    Boige, Valerie
    Malka, David
    Elias, Dominique
    Castaing, Marine
    De Baere, Thierry
    Goere, Diane
    Dromain, Clarisse
    Pocard, Marc
    Ducreux, Michel
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2008, 15 (01) : 219 - 226
  • [3] Trends in long-term survival following liver resection for hepatic colorectal metastases
    Choti, MA
    Sitzmann, JV
    Tiburi, MF
    Sumetchotimetha, W
    Rangsin, R
    Schulick, RD
    Lillemoe, KD
    Yeo, CJ
    Cameron, JL
    [J]. ANNALS OF SURGERY, 2002, 235 (06) : 759 - 765
  • [4] Hepatic arterial oxaliplatin infusion plus intravenous chemotherapy in colorectal cancer with inoperable hepatic metastases: A trial of the Gastrointestinal Group of the Federation Nationale des Centres de Lutte Contre le Cancer
    Ducreux, M
    Ychou, M
    Laplanche, A
    Gamelin, E
    Lasser, P
    Husseini, F
    Quenet, F
    Viret, F
    Jacob, JH
    Boige, V
    Elias, D
    Delperro, JR
    Luboinski, M
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (22) : 4881 - 4887
  • [5] Pharmacokinetic advantage of intra-arterial hepatic oxaliplatin administration: comparative results with cisplatin using a rabbit VX2 tumor model
    Dzodic, R
    Gomez-Abuin, G
    Rougier, P
    Bonnay, M
    Ardouin, P
    Gouyette, A
    Rixe, O
    Ducreux, M
    Munck, JN
    [J]. ANTI-CANCER DRUGS, 2004, 15 (06) : 647 - 650
  • [6] Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer - Analysis of 1001 consecutive cases
    Fong, Y
    Fortner, J
    Sun, RL
    Brennan, MF
    Blumgart, LH
    [J]. ANNALS OF SURGERY, 1999, 230 (03) : 309 - 318
  • [7] Colorectal Liver Metastases Recurrence and Survival Following Hepatic Resection, Radiofrequency Ablation, and Combined Resection-Radiofrequency Ablation
    Gleisner, Ana L.
    Choti, Michael A.
    Assumpcao, Lia
    Nathan, Hari
    Schulick, Richard D.
    Pawlik, Timothy M.
    [J]. ARCHIVES OF SURGERY, 2008, 143 (12) : 1204 - 1212
  • [8] Colorectal hepatic metastases - Resection, local ablation, and hepatic artery infusion pump are associated with prolonged survival
    Heslin, MJ
    Medina-Franco, H
    Parker, M
    Vickers, SM
    Aldrete, J
    Urist, MM
    [J]. ARCHIVES OF SURGERY, 2001, 136 (03) : 318 - 323
  • [9] Cancer statistics, 2005
    Jemal, A
    Murray, T
    Ward, E
    Samuels, A
    Tiwari, RC
    Ghafoor, A
    Feuer, EJ
    Thun, MJ
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2005, 55 (01) : 10 - 30
  • [10] Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer.
    Kemeny, N
    Huang, Y
    Cohen, AM
    Shi, WJ
    Conti, JA
    Brennan, MF
    Bertino, JR
    Turnbull, ADM
    Sullivan, D
    Stockman, J
    Blumgart, LH
    Fong, YM
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (27) : 2039 - 2048
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