Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies

被引：19
作者：
Miles, Michael V. [1 ,2 ,3 ]
Putnam, Philip E. [2 ,4 ]
Miles, Lili [1 ]
Tang, Peter H. [1 ,2 ]
DeGrauw, Antonius J. [2 ,3 ]
Wong, Brenda L. [2 ,3 ]
Horn, Paul S. [2 ,3 ,5 ]
Foote, Heather L. [2 ,6 ]
Rothenberg, Marc E. [2 ,6 ]
机构：
[1] Cincinnati Childrens Hosp, Div Pathol & Lab Med, Dept Pediat, Med Ctr, Cincinnati, OH 45229 USA
[2] Univ Cincinnati, Coll Med, Cincinnati, OH 45229 USA
[3] Cincinnati Childrens Hosp, Div Pediat Neurol, Dept Pediat, Med Ctr, Cincinnati, OH 45229 USA
[4] Cincinnati Childrens Hosp, Div Pediat Gastroenterol Hepatol & Nutr, Dept Pediat, Med Ctr, Cincinnati, OH 45229 USA
[5] Univ Cincinnati, Dept Math Sci, Cincinnati, OH 45221 USA
[6] Cincinnati Childrens Hosp, Div Allergy & Immunol, Dept Pediat, Med Ctr, Cincinnati, OH 45229 USA
来源：
MITOCHONDRION | 2011年 / 11卷 / 01期
关键词：
Allergy; Coenzyme Q10; Food intolerance; Mitochondria; Muscle pathology; Respiratory chain; Electron transport chain; Ubiquinone; MITOCHONDRIAL DISEASE DIAGNOSIS; RESPIRATORY-CHAIN DYSFUNCTION; EOSINOPHILIC ESOPHAGITIS; Q(10) DEFICIENCY; MUSCLE; DISORDERS; HPLC; CHILDHOOD; PREDICTOR; COMPLEXES;
D O I：
10.1016/j.mito.2010.08.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The current study evaluated 23 children (ages 2-16 years) with recurrent food intolerance and allergies for CoQ10 deficiency and mitochondrial abnormalities. Muscle biopsies were tested for CoQ10 levels, pathology, and mitochondrial respiratory chain (MRC) activities. Group 2 (age >10 years; n=9) subjects had significantly decreased muscle CoQ10 than Group 1 (age <10 y; n=14) subjects (p = 0.001) and 16 controls (p<0.05). MRC activities were significantly lower in Group 2 than in Group 1 (p<0.05). Muscle CoQ10 levels in study subjects were significantly correlated with duration of illness (adjusted r(2) = 0.69; p=0.012: n=23). Children with recurrent food intolerance and allergies may acquire CoQ10 deficiency with disease progression. (C) 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
引用
收藏
页码：127 / 135
页数：9
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