Pharmacological effect and toxicity of alkaloids from Gelsemium elegans Benth.

被引：158

作者：

Rujjanawate, C ^{[1
]}

Kanjanapothi, D ^{[1
]}

Panthong, A ^{[1
]}

机构：

[1] Chiang Mai Univ, Res Ctr, Chulabhorn Res Inst, Fac Med,Lab Nat Prod, Chiang Mai 50200, Thailand

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2003年 / 89卷 / 01期

关键词：

Gelsemium elegans; crude alkaloidal fraction; analgesic and anti-inflammatory effect; clonic convulsion; GABA;

D O I：

10.1016/S0378-8741(03)00267-8

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Gelsemium elegans Benth. (Loganiaceae), a toxic plant indigenous to southeastern Asia, is well known among hilltribes as an effective means for committing suicide. A crude alkaloidal fraction from its leaves was isolated by conventional acid-base extraction. Tests in animals showed that the alkaloids exerted analgesic and anti-inflammatory effects. At a lethal dose, the alkaloids produced violent clonic convulsions that led to respiratory failure. Since the convulsions could be prevented by pentobarbital or diazepam and potentiated by reserpine, it is postulated that the alkaloids act centrally against GABA action. (C) 2003 Published by Elsevier Ireland Ltd.

引用

页码：91 / 95

页数：5

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