Pyridine and pyrimidine functionalized half-sandwich Ru(II)-N heterocyclic carbene complexes: Synthesis, structures, spectra, electrochemistry and biological studies

被引：6

作者：

Rana, Bidyut K. ^{[1
,2
]}

Roymahapatra, Gourisankar ^{[1
]}

Das, Himadri Sekhar ^{[1
]}

Giri, Santanab ^{[1
]}

Cardoso, Marlon H. ^{[3
,4
]}

Franco, Octavio L. ^{[3
,4
]}

Nakka, Kiran K. ^{[5
]}

Santra, Manas K. ^{[5
]}

Bag, Partha Pratim ^{[6
]}

Bertolasi, Valerio ^{[7
,8
]}

Dinda, Joydev ^{[9
]}

机构：

[1] Haldia Inst Technol, Sch Appl Sci & Humanities, Haldia 721657, India

[2] Jadavpur Univ, Dept Chem, Kolkata 700032, India

[3] Univ Catolica Dom Bosco, Programa Posgrad Biotecnol, S Inova Biotech, Campo Grande, MS, Brazil

[4] Univ Catolica Brasilia, Ctr Anal Proteom & Bioquim, Programa Posgrad Ciencias Genom & Biotecnol, Brasilia, DF, Brazil

[5] Natl Ctr Cell Sci, Pune, Maharashtra, India

[6] SRM Univ Sikkim, Sch Basic Sci, Dept Chem, Gangtok 37102, Sikkim, India

[7] Univ Ferrara, Dipartimento Chim, Via L Borsari 46, Ferrara, Italy

[8] Univ Ferrara, Ctr Strutturist Diffrattometr, Via L Borsari 46, Ferrara, Italy

[9] Utkal Univ, Dept Chem, Bhubaneswar 751004, India

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2021年 / 1245卷

关键词：

Ru-NHC; Half-sandwich geometry; Spectra; Electrochemistry; DFT; Cytotoxicity; Molecular docking; RUTHENIUM(II) COMPLEXES; EFFICIENT CATALYSTS; ANTICANCER ACTIVITY; ANTITUMOR-ACTIVITY; METAL-COMPLEXES; PROTEIN-BINDING; GOLD(I); POTENT; DNA; COORDINATION;

D O I：

10.1016/j.molstruc.2021.130939

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

New set of Ru-N-Heterocyclic Carbene (Ru-NHC) complexes 1a and 2a were synthesized from their ligand precursors 1-Methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate ( 1) and 1Methyl-2-pyrimidin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate ( 2). The molecules were characterized and their structures were investigated through single crystals X-ray diffraction. The overall coordination around the Ru center can be described as a half-sandwich geometry. Absorption spectra and electrochemical behavior of the complexes were also evaluated, supported by DFT analysis. The complexes were applied on lung (A549), colon (HCT116) and breast (MCF7) cancer cells to examine their in vitro cytotoxicity activity. (c) 2021 Published by Elsevier B.V.

引用

页数：13

共 135 条

[1] Designing metallodrugs with nuclease and protease activity [J].

Agbale, Caleb Mawuli ;

Cardoso, Marlon Henrique ;

Galyuon, Isaac Kojo ;

Franco, Octavio Luiz .

METALLOMICS, 2016, 8 (11) :1159-1169

[2]

Albrecht M, 2001, ANGEW CHEM INT EDIT, V40, P3750, DOI 10.1002/1521-3773(20011015)40:20<3750::AID-ANIE3750>3.0.CO

[3]

2-6

[4]

Aldossary SA, 2019, BIOMED PHARMACOL J, V12, P7, DOI DOI 10.13005/bpj/1608

[5] CIS-DIHALOTETRAKIS(DIMETHYL SULFOXIDE)RUTHENIUM(II) AND TRANS-DIHALOTETRAKIS(DIMETHYL SULFOXIDE)RUTHENIUM(II) COMPLEXES (RUX2(DMSO)4, X = CL, BR) - SYNTHESIS, STRUCTURE, AND ANTITUMOR-ACTIVITY [J].

ALESSIO, E ;

MESTRONI, G ;

NARDIN, G ;

ATTIA, WM ;

CALLIGARIS, M ;

SAVA, G ;

ZORZET, S .

INORGANIC CHEMISTRY, 1988, 27 (23) :4099-4106

[6]

Allardyce CS, 2001, PLATIN MET REV, V45, P62

[7] [Ru(η6-p-cymene)Cl2(pta)] (pta=1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane):: a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells [J].

Allardyce, CS ;

Dyson, PJ ;

Ellis, DJ ;

Heath, SL .

CHEMICAL COMMUNICATIONS, 2001, (15) :1396-1397

[8] Synthesis, X-ray structures, spectroscopic analysis and anticancer activity of novel gold(I) carbene complexes [J].

Altaf, Muhammad ;

Monim-ul-Mehboob, M. ;

Seliman, Adam A. A. ;

Isab, Anvarhusein A. ;

Dhuna, Vikram ;

Bhatia, Gaurav ;

Dhuna, Kshitija .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2014, 765 :68-79

[9] SIR97:: a new tool for crystal structure determination and refinement [J].

Altomare, A ;

Burla, MC ;

Camalli, M ;

Cascarano, GL ;

Giacovazzo, C ;

Guagliardi, A ;

Moliterni, AGG ;

Polidori, G ;

Spagna, R .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1999, 32 :115-119

[10] Strategy to tether organometallic ruthenium-arene anticancer compounds to recombinant human serum albumin [J].

Ang, Wee Han ;

Daldini, Elisa ;

Juillerat-Jeanneret, Lucienne ;

Dyson, Paul J. .

INORGANIC CHEMISTRY, 2007, 46 (22) :9048-9050

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