The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response

被引：6

作者：

Salgado, Ranieri Coelho ^{[1
]}

Fonseca, Dennyson Leandro M. ^{[2
]}

Marques, Alexandre H. C. ^{[2
]}

da Silva Napoleao, Sarah Maria ^{[1
]}

Franca, Tabata Takahashi ^{[1
]}

Akashi, Karen Tiemi ^{[2
]}

de Souza Prado, Caroline Aliane ^{[2
]}

Baiocchi, Gabriela Crispim ^{[1
]}

Placa, Desiree Rodrigues ^{[2
]}

Jansen-Marques, Gabriel ^{[3
]}

Filgueiras, Igor Salerno ^{[1
]}

De Vito, Roberta ^{[4
,5
]}

Freire, Paula Paccielli ^{[1
]}

de Miranda, Gustavo Cabral ^{[1
]}

Saraiva Camara, Niels Olsen ^{[1
]}

Garcia Calich, Vera Lucia ^{[1
]}

Ochs, Hans D. ^{[6
,7
]}

Schimke, Lena F. ^{[1
]}

Jurisica, Igor ^{[8
,9
,10
,11
,12
]}

Condino-Neto, Antonio ^{[1
]}

Cabral-Marques, Otavio ^{[1
,2
,13
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, Brazil

[2] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, SP, Brazil

[3] Univ Sao Paulo, Sch Arts Sci & Humanities, Informat Syst, Sao Paulo, Brazil

[4] Brown Univ, Dept Biostat, Providence, RI 02912 USA

[5] Brown Univ, Data Sci Initiat, Providence, RI 02912 USA

[6] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA

[7] Seattle Childrens Res Inst, Seattle, WA USA

[8] Univ Toronto, Osteoarthrit Res Program, Div Orthoped Surg, Schroeder Arthrit Inst,UHN, Toronto, ON, Canada

[9] Univ Toronto, Data Sci Discovery Ctr, Krembil Res Inst, UHN, Toronto, ON, Canada

[10] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

[11] Univ Toronto, Dept Comp Sci, Toronto, ON, Canada

[12] Slovak Acad Sci, Inst Neuroimmunol, Bratislava, Slovakia

[13] Universal Sci Educ & Res Network USERN, Network Immun Infect Malignancy & Autoimmun NIIMA, Sao Paulo, SP, Brazil

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

基金：

巴西圣保罗研究基金会; 加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

NF-KAPPA-B; CANDIDA-ALBICANS; GENE-EXPRESSION; DENDRITIC CELLS; PATHOGENIC INFLAMMATION; BETA PRODUCTION; R PACKAGE; GAMMA; MACROPHAGES; RECOGNITION;

D O I：

10.1038/s41598-021-99838-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fungal infections represent a major global health problem affecting over a billion people that kills more than 1.5 million annually. In this study, we employed an integrative approach to reveal the landscape of the human immune responses to Candida spp. through meta-analysis of microarray, bulk, and single-cell RNA sequencing (scRNA-seq) data for the blood transcriptome. We identified across these different studies a consistent interconnected network interplay of signaling molecules involved in both Toll-like receptor (TLR) and interferon (IFN) signaling cascades that is activated in response to different Candida species (C. albicans, C. auris, C. glabrata, C. parapsilosis, and C. tropicalis). Among these molecules are several types I IFN, indicating an overlap with antiviral immune responses. scRNA-seq data confirmed that genes commonly identified by the three transcriptomic methods show cell type-specific expression patterns in various innate and adaptive immune cells. These findings shed new light on the anti-Candida immune response, providing putative molecular pathways for therapeutic intervention.

引用

页数：17

共 100 条

[1]

Aggarwal Rakesh, 2016, Perspect Clin Res, V7, P187

[2] Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment [J].

Arendrup, Maiken Cavling ;

Patterson, Thomas F. .

JOURNAL OF INFECTIOUS DISEASES, 2017, 216 :S445-S451

[3] ArrayExpress update - from bulk to single-cell expression data [J].

Athar, Awais ;

Fullgrabe, Anja ;

George, Nancy ;

Iqbal, Haider ;

Huerta, Laura ;

Ali, Ahmed ;

Snow, Catherine ;

Fonseca, Nuno A. ;

Petryszak, Robert ;

Papatheodorou, Irene ;

Sarkans, Ugis ;

Brazma, Alvis .

NUCLEIC ACIDS RESEARCH, 2019, 47 (D1) :D711-D715

[4] STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression [J].

Balic, Jesse J. ;

Albargy, Hassan ;

Luu, Kevin ;

Kirby, Francis J. ;

Jayasekara, W. Samantha N. ;

Mansell, Finbar ;

Garama, Daniel J. ;

De Nardo, Dominic ;

Baschuk, Nikola ;

Louis, Cynthia ;

Humphries, Fiachra ;

Fitzgerald, Katherine ;

Latz, Eicke ;

Gough, Daniel J. ;

Mansell, Ashley .

NATURE COMMUNICATIONS, 2020, 11 (01)

[5] NCBI GEO: archive for functional genomics data sets-update [J].

Barrett, Tanya ;

Wilhite, Stephen E. ;

Ledoux, Pierre ;

Evangelista, Carlos ;

Kim, Irene F. ;

Tomashevsky, Maxim ;

Marshall, Kimberly A. ;

Phillippy, Katherine H. ;

Sherman, Patti M. ;

Holko, Michelle ;

Yefanov, Andrey ;

Lee, Hyeseung ;

Zhang, Naigong ;

Robertson, Cynthia L. ;

Serova, Nadezhda ;

Davis, Sean ;

Soboleva, Alexandra .

NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) :D991-D995

[6] Recognition of yeast nucleic acids triggers a host-protective type I interferon response [J].

Biondo, Carmelo ;

Signorino, Giacomo ;

Costa, Alessandro ;

Midiri, Angelina ;

Gerace, Elisabetta ;

Galbo, Roberta ;

Bellantoni, Antonella ;

Malara, Antonio ;

Beninati, Concetta ;

Teti, Giuseppe ;

Mancuso, Giuseppe .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2011, 41 (07) :1969-1979

[7] Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type I responses [J].

Bohnenkamp, Hermann R. ;

Papazisis, Konstantinos T. ;

Burchell, Joy M. ;

Taylor-Papadimitriou, Joyce .

CELLULAR IMMUNOLOGY, 2007, 247 (02) :72-84

[8] Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-γ:: a molecular basis for priming and synergism with bacterial lipopolysaccharide [J].

Bosisio, D ;

Polentarutti, N ;

Sironi, M ;

Bernasconi, S ;

Miyake, K ;

Webb, GR ;

Martin, MU ;

Mantovani, A ;

Muzio, M .

BLOOD, 2002, 99 (09) :3427-3431

[9] Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-β Signaling [J].

Bourgeois, Christelle ;

Majer, Olivia ;

Frohner, Ingrid E. ;

Lesiak-Markowicz, Iwona ;

Hildering, Kwang-Soo ;

Glaser, Walter ;

Stockinger, Silvia ;

Decker, Thomas ;

Akira, Shizuo ;

Mueller, Mathias ;

Kuchler, Karl .

JOURNAL OF IMMUNOLOGY, 2011, 186 (05) :3104-3112

[10] Aberrant type 1 immunity drives susceptibility to mucosal fungal infections [J].

Break, Timothy J. ;

Oikonomou, Vasileios ;

Dutzan, Nicolas ;

Desai, Jigar, V ;

Swidergall, Marc ;

Freiwald, Tilo ;

Chauss, Daniel ;

Harrison, Oliver J. ;

Alejo, Julie ;

Williams, Drake W. ;

Pittaluga, Stefania ;

Lee, Chyi-Chia R. ;

Bouladoux, Nicolas ;

Swamydas, Muthulekha ;

Hoffman, Kevin W. ;

Greenwell-Wild, Teresa ;

Bruno, Vincent M. ;

Rosen, Lindsey B. ;

Lwin, Wint ;

Renteria, Andy ;

Pontejo, Sergio M. ;

Shannon, John P. ;

Myles, Ian A. ;

Olbrich, Peter ;

Ferre, Elise M. N. ;

Schmitt, Monica ;

Martin, Daniel ;

Barber, Daniel L. ;

Solis, Norma, V ;

Notarangelo, Luigi D. ;

Serreze, David, V ;

Matsumoto, Mitsuru ;

Hickman, Heather D. ;

Murphy, Philip M. ;

Anderson, Mark S. ;

Lim, Jean K. ;

Holland, Steven M. ;

Filler, Scott G. ;

Afzali, Behdad ;

Belkaid, Yasmine ;

Moutsopoulos, Niki M. ;

Lionakis, Michail S. .

SCIENCE, 2021, 371 (6526) :252-+

← 1 2 3 4 5 6 7 8 9 10 →