IHDIP: a controlled randomized trial to assess the security and effectiveness of the incremental hemodialysis in incident patients

被引：34

作者：

Deira, Javier ^{[1
]}

Suarez, Miguel A. ^{[2
]}

Lopez, Francisca ^{[3
]}

Garcia-Cabrera, Emilio ^{[4
]}

Gascon, Antonio ^{[5
]}

Torregrosa, Eduardo ^{[6
]}

Garcia, Giannina E. ^{[7
]}

Huertas, Jorge ^{[8
]}

de la Flor, Jose C. ^{[9
]}

Puello, Suleya ^{[10
]}

Gomez-Raja, Jonathan ^{[11
]}

Grande, Jesus ^{[12
]}

Lerma, Jose L. ^{[13
]}

Corradino, Carlos ^{[14
]}

Musso, Carlos ^{[14
]}

Ramos, Manuel ^{[15
]}

Martin, Jesus ^{[16
]}

Basile, Carlo ^{[17
]}

Casino, Francesco G. ^{[17
,18
]}

机构：

[1] Hosp San Pedro de Alcantara, Caceres, Spain

[2] Hosp Virgen Del Puerto, Plasencia, Spain

[3] Hosp Costa del Sol, Marbella, Spain

[4] Delos Clin Res Org, Seville, Spain

[5] Hosp Obispo Polanco, Teruel, Spain

[6] Hosp Manises, Valencia, Spain

[7] Hosp Arquitecto Marcide, Ferrol, Spain

[8] Hosp Especialidades Fuerzas Armadas, Quito, Ecuador

[9] Hosp Cent Def Gomez Ulla, Madrid, Spain

[10] Hosp Clin Univ, Santiago De Compostela, Spain

[11] FundeSalud, Merida, Spain

[12] Hosp Virgen Concha, Zamora, Spain

[13] Complejo Asistencial Univ, Salamanca, Spain

[14] Hosp Durand Buenos Aires, Buenos Aires, DF, Argentina

[15] Hosp Jerez, Cadiz, Spain

[16] Hosp Nuestra Sra Sonsoles, Avila, Spain

[17] Miulli Gen Hosp, Div Nephrol, Clin Res Branch, Bari, Italy

[18] Dialysis Ctr SM2, Potenza, Italy

来源：

BMC NEPHROLOGY | 2019年 / 20卷 / 1期

关键词：

Once-weekly haemodialysis; Twice-weekly haemodialysis; Incremental haemodialysis progressive hemodialysis; Randomized clinical trial; RESIDUAL RENAL-FUNCTION; KIDNEY-FUNCTION; FREQUENT HEMODIALYSIS; DIALYSIS PATIENTS; MORTALITY; PRESERVATION; EQUATION; ADEQUACY; SOLUTES; START;

D O I：

10.1186/s12882-018-1189-6

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundMost people who make the transition to renal replacement therapy (RRT) are treated with a fixed dose thrice-weekly hemodialysis reegimen, without considering their residual kidney function (RKF). Recent papers inform us that incremental hemodialysis is associated with preservation of RKF, whenever compared with conventional hemodialysis. The objective of the present controlled randomized trial (RCT) is to determine if start HD with one sessions per week (1-Wk/HD), it is associated with better patient survival and other safety parameters.Methods/designIHDIP is a multicenter RCT experimental open trial. It is randomized in a 1:1 ratio and controlled through usual clinical practice, with a low intervention level and non-commercial. It includes 152 incident patients older than 18years, with a RRF of 4ml/min/1.73m2, measured by renal clearance of urea (KrU). The intervention group includes 76 patients who will start with incremental HD (1-Wk/HD). The control group includes 76 patients who will start with thrice-weekly hemodialysis regimen. The primary outcome is assessing the survival rate, while the secondary outcomes are the morbidity rate, the clinical parameters, the quality of life and the efficiency.DiscussionThis study will enable to know the number of sessions a patient should receive when starting HD, depending on his RRF. The potentially important clinical and financial implications of incremental hemodialysis warrant this RCT.Trial registrationU.S. National Institutes of Health, ClinicalTrials.gov. Number: NCT03239808, completed 13/04/2017. Sponsor: Foundation for Training and Research of Health Professionals of Extremadura.

引用

页数：8

共 36 条

[1]

[Anonymous], HEM INCR PAC INC IHD

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