Differences in survival outcome between oropharyngeal and oral cavity squamous cell carcinoma in relation to HPV status

被引：22

作者：

Lai, Kenneth ^{[1
,2
,3
,4
]}

Killingsworth, Murray ^{[2
,3
,4
,5
]}

Matthews, Slade ^{[6
,7
]}

Caixeiro, Nicole ^{[2
,3
]}

Evangelista, Carlyn ^{[4
]}

Wu, Xiao ^{[4
]}

Wykes, James ^{[5
,8
]}

Samakeh, Alan ^{[8
]}

Forstner, Dion ^{[5
,9
]}

Niles, Navin ^{[8
]}

Hong, Angela ^{[10
]}

Lee, Cheok Soon ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Sydney, Bosch Inst, Canc Pathol, Sydney, NSW, Australia

[2] Western Sydney Univ, Sch Med, Discipline Pathol, Sydney, NSW, Australia

[3] Ingham Inst Appl Med Res, Ctr Oncol Educ & Res Translat CONCERT, Sydney, NSW, Australia

[4] Liverpool Hosp, Dept Anat Pathol, SSWPS, Sydney, NSW, Australia

[5] Univ New South Wales, South Western Sydney Clin Sch, Fac Med, Sydney, NSW, Australia

[6] Univ Sydney, Sydney Med Sch Pharmacol, Sydney, NSW, Australia

[7] Univ Sydney, Bosch Inst, Sydney, NSW, Australia

[8] Liverpool Hosp, Dept Head & Neck Surg, Sydney, NSW, Australia

[9] Liverpool Hosp, Dept Radiat Oncol, Sydney, NSW, Australia

[10] Univ Sydney, Cent Clin Sch, Sydney, NSW, Australia

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2017年 / 46卷 / 08期

关键词：

human papilloma virus; oral cavity; oropharyngeal; squamous cell carcinoma; survival outcome; HUMAN-PAPILLOMAVIRUS INFECTION; CANCER INCIDENCE; SEXUAL-BEHAVIOR; RISK-FACTORS; NECK-CANCER; TRENDS; HEAD; THERAPY; DNA;

D O I：

10.1111/jop.12535

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

BackgroundThis study examined the prognostic significance of human papillomavirus (HPV) in patients with oropharyngeal and oral cavity squamous cell carcinoma (SCC). MethodsTissue microarrays were constructed from oropharyngeal and oral cavity SCC (n=143). The presence of functional HPV in tumour was determined by combined assessments of p16 immunohistochemistry and HPV insitu hybridisation. ResultsOropharyngeal SCC patients presented with more advanced disease in comparison with oral cavity SCC patients (P=0.001). HPV is present in 60% and 61% of oropharyngeal and oral cavity SCC patients, respectively. HPV-positive oropharyngeal SCC patients with advanced TNM stages displayed better overall and disease-free survival outcomes than HPV-negative patients (P=0.022 and 0.046, respectively). Such survival differences were not observed in oral cavity SCC. ConclusionsHPV is common in both oropharyngeal and oral cavity SCC and is associated with better survival outcome in oropharyngeal SCC but not in oral cavity SCC patients.

引用

页码：574 / 582

页数：9

共 28 条

[21] The role of sexual behavior in head and neck cancer: implications for prevention and therapy [J].