Primitive origins of prostate cancer: In vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells

被引：52
作者：
Goldstein, Andrew S. [2 ]
Stoyanova, Tanya [3 ]
Witte, Owen N. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90095 USA
来源：
MOLECULAR ONCOLOGY | 2010年 / 4卷 / 05期
关键词：
Prostate cancer; Cancer-initiation; Stem cell; Tissue-regeneration; Castration-resistance; EPITHELIAL STEM-CELLS; ACUTE MYELOID-LEUKEMIA; MURINE PROSTATE; NEUROENDOCRINE DIFFERENTIATION; BASAL-CELLS; BETA-CATENIN; HEMATOPOIETIC STEM; ANDROGEN-RECEPTOR; PROGENITOR CELLS; FUNCTIONAL-CHARACTERIZATION;
D O I：
10.1016/j.molonc.2010.06.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tissue stem cells have been linked to cancers of epithelial origin including the prostate. There are three relevant issues concerning stem cells and cancer that rely solely on functional studies: 1. Are there tissue-regenerating stem cells in the adult organ? 2. Can tissue-regenerating cells serve as targets for transformation? 3. Do primary tumors contain tumor-propagating (cancer stem) cells? We will review the recent literature with respect to these critical issues to provide a direct link between primitive cells and prostate cancer. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：385 / 396
页数：12
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