Cellular targets of interleukin-18 in rheumatoid arthritis

被引：40
作者：
Dai, Sheng-Ming
Shan, Zheng-Zheng
Xu, Huji
Nishioka, Kusuki
机构：
[1] Second Mil Med Univ, Changhai Hosp, Dept Rheumatol & Immunol, Shanghai 200433, Peoples R China
[2] Second Mil Med Univ, Changzheng Hosp, Dept Rheumatol & Immunol, Shanghai 200433, Peoples R China
[3] St Marianna Univ, Sch Med, Inst Med Sci, Dept Bioregulat, Kawasaki, Kanagawa, Japan
来源：
ANNALS OF THE RHEUMATIC DISEASES | 2007年 / 66卷 / 11期
关键词：
D O I：
10.1136/ard.2006.067793
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent data are presented which indicate a critical role for interleukin ( IL)- 18 in rheumatoid arthritis ( RA). The T cells and macrophages invading the synovium or in the synovial fluid are the chief cellular targets of IL- 18 in RA. Neutrophils, dendritic cells and endothelial cells may also be cellular mediators of IL-18. The direct effect of IL- 18 on fibroblast- like synoviocytes or chondrocytes may not be essential or important. In RA, IL- 18, which is mainly produced by macrophages, activates T cells and macrophages to produce proinflammatory cytokines, chemokines, adhesion molecules and RANKL which, in turn, perpetuate chronic inflammation and induce bone and cartilage destruction.
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页码：1411 / 1418
页数：8
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