Synthetic nanosensors for imaging neuromodulators

被引：3

作者：

Del Bonis-O'Donnell, Jackson Travis ^{[1
]}

Mun, Jaewan ^{[1
]}

Delevich, Kristen ^{[2
]}

Landry, Markita P. ^{[1
,3
,4
,5
]}

机构：

[1] Univ Calif Berkeley, Dept Chem & Biomol Engn, Berkeley, CA 94720 USA

[2] Washington State Univ, Coll Vet Med, Dept Integrat Physiol & Neurosci, Pullman, WA 99164 USA

[3] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[4] Calif Inst Quantitat Biosci QB3, Berkeley, CA USA

[5] Chan Zuckerberg Biohub, San Francisco, CA USA

来源：

JOURNAL OF NEUROSCIENCE METHODS | 2021年 / 363卷

关键词：

Single-walled carbon nanotubes (SWNTs); Neuromodulation; Dopamine; Near infrared imaging; PHASE MOLECULAR RECOGNITION; IN-VIVO; DOPAMINE; NEUROTRANSMITTER; NANOTUBES; REVEALS; SENSORS;

D O I：

10.1016/j.jneumeth.2021.109326

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuromodulation plays a critical role in regulating brain function and its dysregulation is implicated in the pathogenesis of numerous neurological and psychiatric disorders. However, only in the last few years have optical tools become available to probe the spatial and temporal profiles of neuromodulator signaling, including dopamine, with the requisite resolution to uncover mechanisms of neuromodulation. In this review, we summarize the current state of synthetic nanomaterial-based optical nanosensors for monitoring neurotransmission with high spatial and temporal resolution. Specifically, we highlight how synthetic nanosensors can elucidate the spatial distribution of neuromodulator release sites and report the temporal dynamics and spatial diffusion of neuromodulator release. Next, we outline advantages and limitations of currently available nanosensors and their recent application to imaging endogenous dopamine release in brain tissue. Finally, we discuss strategies to improve nanosensors for in vivo use, with implications for translational applications.

引用

页数：7

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