Justicidin B: A Promising Bioactive Lignan

被引:50
|
作者
Hemmati, Shiva [1 ,2 ]
Seradj, Hassan [3 ]
机构
[1] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmaceut Biotechnol, POB 71345-1583, Shiraz, Iran
[2] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, POB 71345-3119, Shiraz, Iran
[3] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmacognosy, POB 71345-1583, Shiraz, Iran
关键词
lignan; arylnaphthalene; justicidin B; distribution; chemistry; biosynthesis; biotechnological production; biological activity; synthesis; chromatography; IN-VITRO CULTURES; PINORESINOL-LARICIRESINOL REDUCTASES; HAYATAI VAR DECUMBENS; LINUM-PERENNE; ARYLNAPHTHALENE LIGNAN; DIRIGENT PROTEIN; CELL-CULTURES; ARYLNAPHTALENE LIGNAN; ANTINEOPLASTIC AGENTS; CHEMICAL-CONSTITUENTS;
D O I
10.3390/molecules21070820
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Adverse effects and drug resistance to the current onchopharmacologicals have increased the demand for alternative novel therapeutics. We herein introduce justicidin B, an arylnaphthalen lignan isolated from different plant origins, especially Justicia, Phyllanthus, Haplophyllum and Linum species. This cyclolignan exhibits a wide array of biological properties ranges from piscicidal to antifungal, antiviral and antibacterial activities. Activity against Trypanosoma brucei makes justicidin B a potential antiprotozoal agent for the treatment of neglected tropical diseases. Pharmacological properties like antiplatelet, anti-inflammatory and bone resorption inhibition have been also attributed to justicidin B. This compound is a potent cytotoxic substance on several cell lines, especially chronic myeloid and chronic lymphoid leukemia. Pharmacological values, natural variation, as well as biotechnological production of justicidin B by plant cell, tissue and organ culture are also described in this review. Chemical characteristics and chromatographic methods to identify justicidin B and its biosynthetic pathway have been discussed. Different approaches to the total synthesis of justicidin B are compared. This review would shed light on the role of justicidin B as an intriguing natural compound and provides a chance to optimize conditions for industrial applications.
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页数:20
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