Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil

被引：28
作者：
Brum, Doralina Guimaraes
Barreira, Amilton Antunes
Louzada-Junior, Paulo
Mendes-Junior, Celso Teixeira
Donadi, Eduardo Antonio
机构：
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Med, Div Clin Immunol, BR-14049 Ribeirao Preto, Brazil
[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Neurol, BR-14049 Ribeirao Preto, Brazil
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 189卷 / 1-2期
基金：
巴西圣保罗研究基金会;
关键词：
HLA-DRB1*15; HLA-DRB1*1501; HLA-DRB1*1503; multiple sclerosis; Brazilians;
D O I：
10.1016/j.jneuroim.2007.06.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Multiple sclerosis (MS) is a multifactorial inflammatory disease that primarily affects the central nervous system. Genes and environmental factors probably interact in MS susceptibility and outcome; however, their roles have not been elucidated yet. The evaluation of the HLA-DRB1 gene in the Brazilian population is of particular interest in evidencing the behavior of HLA-DRB1 alleles in a highly admixed population inserted in an environment of low MS prevalence. The present results suggest that a given HLA-DRB1 allele may exhibit different behaviors, i.e. confer resistance or susceptibility, in response to the environmental and/or genetic (ethnic) backgrounds that characterize a sampled population. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：118 / 124
页数：7
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