Tyrosinase inhibitors as potential antibacterial agents

被引:70
作者
Yuan, Ye [1 ,2 ]
Jin, Wanli [2 ]
Nazir, Yasir [2 ]
Fercher, Christian [3 ]
Blaskovich, Mark A. T. [2 ]
Cooper, Matthew A. [2 ]
Barnard, Ross T. [1 ]
Ziora, Zyta M. [2 ]
机构
[1] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia
[2] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia
[3] Univ Queensland, AIBN, Brisbane, Qld 4072, Australia
关键词
Antibacterial activity; Anti-melanogenic activity; Plant extract; Tyrosinase inhibitors; ANTI-TYROSINASE; ALOE-EMODIN; KOJIC ACID; MUSHROOM TYROSINASE; ANTIMICROBIAL ACTIVITIES; MELANIN SYNTHESIS; RICE BRAN; ANTIOXIDANT; ANTICANCER; FLAVONOIDS;
D O I
10.1016/j.ejmech.2019.111892
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Tyrosinase is a copper-containing enzyme that catalyzes the biosynthesis of melanin. This enzyme is present in bacteria, fungi, plants and animals, and plays multiple roles in pigmentation, wound healing, radiation protection, primary immune responses and the undesirable browning of fruits and vegetables. Selective tyrosinase inhibitors hence have potential application in diverse areas of agriculture, cosmetics and pharmaceuticals. In the past decade many natural and synthetic tyrosinase inhibitors have been evaluated, with many reported to also possess intrinsic antibacterial activity. Further, the enzyme product melanin has been shown to compromise the activity of traditional antibiotics. Due to the antibiotic resistance crisis and the slow development of new antibiotics, tyrosinase inhibitors may have potential for development of novel antimicrobials or antibiotic adjuvants that enhance activity of incumbent drugs. This review focuses on the antibacterial activity of natural and synthetic tyrosinase inhibitors reported in the past ten years and explores the possibilities for synergism of anti-tyrosinase with anti-bacterials. (C) 2019 Elsevier Masson SAS. All rights reserved.
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页数:12
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