High-Fat Diet Impacts on Tumor Development in the Gut

被引：12

作者：

van Driel, Milou S. ^{[1
,2
,3
]}

van Neerven, Sanne M. ^{[1
,2
,3
]}

Vermeulen, Louis ^{[1
,2
,3
]}

机构：

[1] Univ Amsterdam, Med Ctr, Canc Ctr Amsterdam, Lab Expt Oncol & Radiobiol,Ctr Expt & Mol Med, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Med Ctr, Amsterdam Gastroenterol & Metab, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[3] Oncode Inst, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

来源：

TRENDS IN CANCER | 2021年 / 7卷 / 08期

关键词：

CANCER;

D O I：

10.1016/j.trecan.2021.06.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A high-fat diet (HFD) directly acts on intestinal stem cells by increasing their numbers and proliferation, resulting in an elevated risk of developing colorectal cancer (CRC). In a recent study, Mana et al. revealed that HFD-mediated intestinal tumor formation can be reduced by inhibiting fatty acid oxidation.

引用

页码：664 / 665

页数：2

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