Worsening of Graves' ophthalmopathy after SARS-CoV-2 mRNA vaccination

被引：13

作者：

Patrizio, Armando ^{[1
]}

Ferrari, Silvia Martina ^{[2
]}

Antonelli, Alessandro ^{[3
,5
]}

Fallahi, Poupak ^{[4
]}

机构：

[1] Azienda Osped Univ Pisana, Dept Emergency Med, Pisa, Italy

[2] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

[3] Univ Pisa, Dept Surg, Med & Mol Pathol & Crit Area, Pisa, Italy

[4] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Pisa, Italy

[5] Univ Pisa, Med & Mol Pathol & Crit Area, Lab Primary Human Cells, Immuno Endocrine Sect Internal Med,Dept Surg,Med,E, Via Savi 10, I-56126 Pisa, Italy

来源：

AUTOIMMUNITY REVIEWS | 2022年 / 21卷 / 07期

关键词：

Graves' ophthalmopathy; SARS-CoV-2; Vaccine; Graves' disease; COVID-19;

D O I：

10.1016/j.autrev.2022.103096

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

More reports are documenting how vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could represent new external triggers for autoimmune endocrine diseases (AIED) in patients with indi-vidual predisposition. We report two cases of Graves' Ophthalmopathy (GO) recrudescence few days after the administration of BNT162B2 (Pfizer-BioNTech) SARS-CoV-2 vaccine. Even if causality relationship cannot be excluded, the development of these events could be explained through immune mediated mechanism such as the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). While further investigations are necessary to improve our knowledge of the underlying pathogenesis of these phenomena, caution may be warranted when vaccinating individuals with known autoimmune diseases.

引用

页数：2

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