Complexation in a β-cyclodextrin-salicylic acid system

被引：25

作者：

Belyakova, L. A. ^{[1
]}

Varvarin, A. M. ^{[1
]}

Lyashenko, D. Yu. ^{[1
]}

Khora, O. V. ^{[1
]}

Oranskaya, E. I. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Surface Chem, UA-03164 Kiev 164, Ukraine

来源：

COLLOID JOURNAL | 2007年 / 69卷 / 05期

关键词：

D O I：

10.1134/S1061933X0705002X

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Inclusion host-guest complexes are synthesized from beta-cyclodextrin and salicylic acid, which is a nonsteroid anti-inflammatory drug with a wide range of action. By IR and UV spectroscopy, and X-ray diffraction, and thermogravimetry, it is established that axial 1:1 complexes of the "tail forward" type are formed due to the dispersion interactions between internal hydrophobic cavities of beta-cyclodextrin molecules and salicylic acid aromatic rings. Salicylic acid is stabilized due to the fact that its carboxyl group is located in the plane of the upper edge of beta-cyclodextrin molecule and weak hydrogen bond is formed between phenyl hydroxyl and glycoside oxygen. The encapsulation of salicylic acid changes its crystal structure and thermal stability.

引用

页码：546 / 551

页数：6

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