The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined

被引：27
作者：
Jin, Lei [1 ,2 ]
Liu, Wei-Ren [1 ,2 ]
Tian, Meng-Xin [1 ,2 ]
Fan, Jia [1 ,2 ,3 ]
Shi, Ying-Hong [1 ,2 ]
机构：
[1] Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Dept Liver Surg, 180 FengLin Rd, Shanghai 200032, Peoples R China
[2] Minist Educ, Key Lab Carcinogenesis & Canc Invas, 180 FengLin Rd, Shanghai 200032, Peoples R China
[3] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China
来源：
WORLD JOURNAL OF SURGICAL ONCOLOGY | 2016年 / 14卷
基金：
中国国家自然科学基金;
关键词：
SphKs/S1P/S1PR1; Immunity; Cancer; SPHINGOSINE KINASE 1; PERSISTENT STAT3 ACTIVATION; BONE-MARROW; LYMPHOCYTE EGRESS; PROGENITOR CELLS; SPHINGOLIPID MEDIATORS; SELECTIVE-INHIBITION; THERAPEUTIC TARGETS; MULTIPLE-SCLEROSIS; SIGNALING PATHWAY;
D O I：
10.1186/s12957-016-0884-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Over the past two decades, huge amounts of research were launched to understand the functions of sphingosine. Many pathways were uncovered that convey the relative functions of biomacromolecules. In this review, we discuss the recent advances of the role of the SphKs/S1P/S1PR1 axis in immunity and cancer. Finally, we investigate the therapeutic potential of new drugs that target S1P signaling in cancer therapy.
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页数：8
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