Possible involvement of calpain in the growth of estrogen receptor positive breast cancer cells

被引：0

作者：

Shiba, E

Kim, SS

Fujitani, M

Kambayashi, J

Kawamura, I

Tsujimoto, S

Shimomura, K

Tanji, Y

Taguchi, T

Kimoto, Y

Izukura, M

Takai, S

机构：

[1] OSAKA UNIV,SCH MED,DEPT SURG 2,SUITA,OSAKA 565,JAPAN

[2] FUJISAWA PHARMACEUT CO LTD,PHARMACOL RES LABS,YODOGAWAKU,OSAKA 532,JAPAN

来源：

ANTICANCER RESEARCH | 1996年 / 16卷 / 02期

关键词：

breast cancer; calpain; calpain inhibitor; estrogen receptor; MCF-7;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Calpain (Ca2+-activated neutral protease, EC 3.4.22.17) has been reported to hydrolyze the estrogen receptor (ER). However, there has been no report available regarding the role of calpain in the growth of breast cancer cells. To investigate the role of calpain in the growth of various breast cancer cell lines, we employed a synthetic peptide, calpeptin, which is a cell permeable specific inhibitor of calpain. Calpeptin inhibited the cell growth of ER positive breast cancer cells, such as MCF-7, T-47D, ZR-75-1 in a dose dependent manner in the presence of E(2). However, the growth of ER negative breast cancer cells, MDA-MB-231, was not inhibited by calpeptin. It is suggested that calpain plays an important role in the growth of ER positive breast cancer cells.

引用

页码：773 / 777

页数：5

共 11 条

[1]

ARIYOSHI H, 1991, BIOCHEM INT, V23, P1019

[2] PHENOL RED IN TISSUE-CULTURE MEDIA IS A WEAK ESTROGEN - IMPLICATIONS CONCERNING THE STUDY OF ESTROGEN-RESPONSIVE CELLS IN CULTURE [J].