The dark side of SARS-CoV-2 rapid antigen testing: screening asymptomatic patients

被引:19
作者
Caruana, G. [1 ,2 ]
Lebrun, L-L [3 ]
Aebischer, O. [3 ]
Opota, O. [1 ,2 ]
Urbano, L. [3 ]
de Rham, M. [4 ]
Marchetti, O. [3 ]
Greub, G. [1 ,2 ,5 ]
机构
[1] Lausanne Univ Hosp, Inst Microbiol, Lausanne, Switzerland
[2] Univ Lausanne, Lausanne, Switzerland
[3] Ensemble Hosp Cote EHC, Patients Safety Program, Morges, Switzerland
[4] Ensemble Hosp Cote EHC, CoVID 19 Task Force Direct, Morges, Switzerland
[5] Lausanne Univ Hosp, Dept Med, Infect Dis Div, Lausanne, Switzerland
关键词
COVID-19 diagnostic testing; emergency ward; health plan implementation; rapid antigen test; SARS-CoV-2;
D O I
10.1016/j.nmni.2021.100899
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Several reports showed SARS-CoV-2 rapid antigen tests (RATs) performances among COVID-19 symptomatic subjects in outpatient settings during periods of highest incidence of infections and high rates of hospital admissions, but few data are present for asymptomatic patients. We investigated the role of RATs in an emergency department, as a novel screening tool before admission for COVID-19 asymptomatic patients. A total of 116 patients were screened on admission in a 250-bed community hospital in Morges, Switzerland. RAT detected 2/7 RT-PCR-positive patients and delivered two false-positive results. These data suggest the non-fiability of RATs screening in this clinical scenario. (c) 2021 The Author(s). Published by Elsevier Ltd.
引用
收藏
页数:3
相关论文
共 10 条
[1]  
[Anonymous], 2020, Rolling Updates on Coronavirus Disease (COVID-19)
[2]  
[Anonymous], COVID 19 SIT UPD WOR
[3]   Diagnostic strategies for SARS-CoV-2 infection and interpretation of microbiological results [J].
Caruana, G. ;
Croxatto, A. ;
Coste, A. T. ;
Opota, O. ;
Lamoth, F. ;
Jaton, K. ;
Greub, G. .
CLINICAL MICROBIOLOGY AND INFECTION, 2020, 26 (09) :1178-1182
[4]   Implementing SARS-CoV-2 Rapid Antigen Testing in the Emergency Ward of a Swiss University Hospital: The INCREASE Study [J].
Caruana, Giorgia ;
Croxatto, Antony ;
Kampouri, Eleftheria ;
Kritikos, Antonios ;
Opota, Onya ;
Foerster, Maryline ;
Brouillet, Rene ;
Senn, Laurence ;
Lienhard, Reto ;
Egli, Adrian ;
Pantaleo, Giuseppe ;
Carron, Pierre-Nicolas ;
Greub, Gilbert .
MICROORGANISMS, 2021, 9 (04)
[5]  
Fenollar F, 2020, J CLIN MICROBIOL
[6]  
FOPH, COR TESTS
[7]   SARS-CoV-2 antigen rapid immunoassay for diagnosis of COVID-19 in the emergency department [J].
Moeckel, Martin ;
Corman, Victor M. ;
Stegemann, Miriam S. ;
Hofmann, Joerg ;
Stein, Angela ;
Jones, Terry C. ;
Gastmeier, Petra ;
Seybold, Joachim ;
Offermann, Ralf ;
Bachmann, Ulrike ;
Lindner, Tobias ;
Bauer, Wolfgang ;
Drosten, Christian ;
Rosen, Alexander ;
Somasundaram, Rajan .
BIOMARKERS, 2021, 26 (03) :213-220
[8]   Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples [J].
Opota, Onya ;
Brouillet, Rene ;
Greub, Gilbert ;
Jaton, Katia .
PATHOGENS AND DISEASE, 2020, 78 (08)
[9]  
Schwob J-M, 2020, MEDXRIV
[10]  
Turcato G, 2020, J INFECT