Hemochromatosis and Hepatocellular Carcinoma Secondary to Immunoglobulin G4-Related Disease with Hepatopathy: A Case Report

被引:0
作者
Kanaka, Shintaro [1 ]
Kawano, Youichi [2 ]
Yokomuro, Shigeki [2 ]
Ando, Fumihiko [2 ]
Itokawa, Norio [3 ]
Hatori, Tsutomu [4 ]
Matsumoto, Koshi [5 ]
Zen, Yoh [6 ]
Miyashita, Masao [2 ]
Yoshida, Hiroshi [1 ]
机构
[1] Nippon Med Sch, Dept Surg, Tokyo, Japan
[2] Nippon Med Sch, Dept Surg, Chiba Hokusoh Hosp, Chiba, Japan
[3] Nippon Med Sch, Dept Internal Med, Div Gastroenterol, Chiba Hokusoh Hosp, Chiba, Japan
[4] Nippon Med Sch, Dept Clin Pathol, Chiba Hokusoh Hosp, Chiba, Japan
[5] Ebina Gen Hosp, Dept Pathol, Ebina, Kanagawa, Japan
[6] Kobe Univ, Dept Diagnost Pathol, Grad Sch Med, Kobe, Hyogo, Japan
关键词
IgG4-related disease; IgG4-hepatopathy; secondary hemochromatosis; hepatocellular carcinoma; AUTOIMMUNE HEPATITIS; DIAGNOSIS;
D O I
10.1272/jnms.JNMS.2021_88-306
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Immunoglobulin G4-related disease (IgG4-RD) is a recently characterized illness in which lymphocytes and plasma cells infiltrate various anatomical sites. IgG4-hepatopathy, a manifestation of IgG4-RD, is a broader term covering various patterns of liver injury. The clinical course, including the malignant potential of IgG4-RD, remains unclear. Here we report the first case of secondary hemochromatosis and hepatocellular carcinoma (HCC) developing from IgG4-hepatopathy. A 67-year-old man was admitted to our hospital for treatment of deteriorating glucose tolerance. Blood test results showed hypergam-maglobulinemia, especially IgG4. He was readmitted 2 months later with dyspnea due to lung disease and pleural effusion, and elevated transaminase levels. He underwent liver and lung biopsies. IgG4-RD was diagnosed and he was treated with steroid therapy, which improved serum IgG4 levels and imaging abnormalities. A follow-up computed tomography (CT) scan conducted 38 months later revealed a tumor (diameter, 50 mm) in liver segments 7 and 8. The resected specimen revealed HCC and abundant siderosis in the background liver, indicating a diagnosis of hemochromatosis. IgG4-positive cells were scarce, probably because of corticosteroid therapy. In the present case, IgG4-RD was well controlled with prednisolone (PSL) and an immunosuppressive agent, and chronic hepatitis was not severe, even though the patient subsequently developed HCC. However, extensive siderosis consistent with hemochromatosis was unexpectedly noted. These findings suggest that secondary hemochromatosis and HCC developed during IgG4-RD with hepatopathy. We believe this case sheds light on IgG4-RD.
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页码:138 / 144
页数:7
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