A gene for recessive nonsyndromic sensorineural deafness (DFNB18) maps to the chromosomal region 11p14-p15.1 containing the Usher syndrome type 1C gene

被引：37
作者：
Jain, PK
Lalwani, AK
Li, XC
Singleton, TL
Smith, TN
Chen, A
Deshmukh, D
Verma, IC
Smith, RJH
Wilcox, ER
机构：
[1] NIDODS, Mol Genet Lab, NIH, Rockville, MD 20850 USA
[2] Univ Calif San Francisco, Sch Med, Dept Otolaryngol Head & Neck Surg, Div Otol Neurotol & Skullbase Surg, San Francisco, CA 94143 USA
[3] Univ Iowa, Dept Otolaryngol Head & Neck Surg, Mol Otolaryngol Res Labs, Iowa City, IA 52242 USA
[4] Deshmukh Nursing Home, Ichalkaranji 416115, Maharashtra, India
[5] All India Inst Med Sci, New Delhi 110029, India
来源：
GENOMICS | 1998年 / 50卷 / 02期
关键词：
D O I：
10.1006/geno.1998.5320
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Autosomal recessive nonsyndromic sensorineural deafness segregating in a large consanguineous Indian family was mapped to chromosome 11p14-p15.1 defining a new locus, DFNB18. A maximum lad scope of 4.4 at Theta = 0 was obtained for the polymorphic microsatellite marker D11S1888. Haplotype analysis localizes this gene between markers D11S1307 and D11S2368, which is approximately 1.6 cM and encompasses the region of Usher syndrome type 1C (USHP1C). We postulate that DFNB18 and USH1C are allelic variants of the same gene. (C) 1998 Academic Press.
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页码：290 / 292
页数：3
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